Literature summary for 2.4.1.248 extracted from

Funane, K.; Nakai, S.; Terasawa, K.; Oguma, T.; Kawamoto, H.; Kitamura, Y.; Kobayashi, M.
Mutation of Bacillus cyclodextran glucanotransferase to increase its reaction velocity (2003), J. Appl. Glycosci., 50, 33-35.

No PubMed abstract available

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Activating Compound

Activating Compound	Comment	Organism	Structure
Ca2+	activation. In mutants A452N and V744L, activation by Ca2+ is reduced	Niallia circulans

Protein Variants

Protein Variants	Comment	Organism
A452N	3fold increase in reaction velocity, 9fold increase in Km value. Activation by Ca2+ and inactivation by Cu2+ are reduced	Niallia circulans
V744L	2fold increase in reaction velocity, 3fold increase in Km value. Activation by Ca2+ and inactivation by Cu2+ are reduced	Niallia circulans

Inhibitors

Inhibitors	Comment	Organism	Structure
1-ethyl-3-[(3-dimethylamino)propyl]carbodiimide	inactivation o both wild-type and mutants A452N and V744L, inactivation is reduced in presence of 10 mM Ca2+	Niallia circulans
Cu2+	inactivation. In mutants A452N and V744L, inactivation by Cu2+ is reduced	Niallia circulans

Organism

Organism	UniProt	Comment	Textmining
Niallia circulans	-	-	-
Niallia circulans T-3040	-	-	-

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Release 2023.1 (January 2023)