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Literature summary for 2.4.1.231 extracted from
- alpha-Retaining glucosyl transfer catalysed by trehalose phosphorylase from Schizophyllum commune: mechanistic evidence obtained from steady-state kinetic studies with substrate analogues and inhibitors (2001), Biochem. J., 360, 727-736.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-deoxynojirimycin | - |
Schizophyllum commune |  |
| 2-amino-2-deoxy-D-glucose | competitive with glucose | Schizophyllum commune | |
| D-glucal | - |
Schizophyllum commune | |
| D-glucono-delta-lactone | - |
Schizophyllum commune | |
| isofagomine | - |
Schizophyllum commune | |
| orthovanadate | competitive against phosphate and alpha-D-glucopyranosyl phosphate, inhibits forward and reverse reaction | Schizophyllum commune | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 31 | - |
alpha-D-glucose | 30°C, pH 6.6 | Schizophyllum commune | |
| 87 | - |
alpha,alpha-trehalose | 30°C, pH 6.6 | Schizophyllum commune | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha,alpha-trehalose + phosphate | Schizophyllum commune | - |
alpha-D-glucose + alpha-D-glucose 1-phosphate | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schizophyllum commune | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha,alpha-trehalose + phosphate | - |
Schizophyllum commune | alpha-D-glucose + alpha-D-glucose 1-phosphate | - |
r | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 10.3 | - |
alpha-D-glucose | 30°C, pH 6.6 | Schizophyllum commune | |
| 14.1 | - |
alpha,alpha-trehalose | 30°C, pH 6.6 | Schizophyllum commune | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1 | - |
orthovanadate | 30°C, pH 6.6 | Schizophyllum commune | |
| 46 | - |
2-amino-2-deoxy-D-glucose | 30°C, pH 6.6 | Schizophyllum commune | |
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