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Literature summary for 2.4.1.228 extracted from

  • Tyler, A.; Johansson, A.; Karlsson, T.; Gudey, S.K.; Braennstroem, T.; Grankvist, K.; Behnam-Motlagh, P.
    Targeting glucosylceramide synthase induction of cell surface globotriaosylceramide (Gb3) in acquired cisplatin-resistance of lung cancer and malignant pleural mesothelioma cells (2015), Exp. Cell Res., 336, 23-32.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information tumour stress activation of glucosylceramide synthase Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
DL-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol i.e. PPMP, a glycosphingolipid synthesis inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
H-1299 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
GCS
-
 Homo sapiens
glucosylceramide synthase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction effect of GCS inhibitor DL-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol and multidrug resistance 1/P-glycoprotein, MDR1, pump inhibitor cyclosporin A on expression and cisplatin cytotoxicity. Enzyme inhibition potentiates cisplatin cytotoxicity in H1299 cells and abolishes cell surface globotriaosylceramide (Gb3) expression of resistant cells Homo sapiens
physiological function Ceramide increases in response to chemotherapy, leading to proliferation arrest and apoptosis. A tumour stress activation of glucosylceramide synthase follows to eliminate ceramide by formation of glycosphingolipids (GSLs) such as globotriaosylceramide (Gb3), the functional receptor of verotoxin-1 Homo sapiens