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Literature summary for 2.4.1.228 extracted from
- Identification and characterization of the human Gb3/CD77 synthase gene promoter (2008), Glycobiology, 18, 1028-1035.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| LPS | - |
Homo sapiens | |
| TNF-alpha | - |
Homo sapiens | |
| transcriptional factor Sp1 | - |
Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | verotoxin induces endothelial cell death via the verotoxin receptor globotriaosylceramide, Gb3/CD77, leading to hemolytic uremic syndrome | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| the human Gb3S promoter is cloned and characterized | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-deoxy-D-glucose | inhibits the Gb3S promoter activity in dose dependent manner | Homo sapiens |  |
| mithramycin A | inhibits the Gb3S promoter activity in dose dependent manner | Homo sapiens | |
| streptozotocin | inhibits the Gb3S promoter activity in dose dependent manner | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-galactose + beta-D-galactosyl-(1-4)-D-glucosyl-(1-1)-ceramide | Homo sapiens | - |
UDP + alpha-D-galactosyl-(1-4)-beta-D-galactosyl-(1-4)-D-glucosyl-(1-1)-ceramide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endothelial cell | endothelial cell surface | Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| NCCIT cell | - |
Homo sapiens | - |
| SK-MEL-28 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-galactose + beta-D-galactosyl-(1-4)-D-glucosyl-(1-1)-ceramide | - |
Homo sapiens | UDP + alpha-D-galactosyl-(1-4)-beta-D-galactosyl-(1-4)-D-glucosyl-(1-1)-ceramide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha1,4-galactosyltransferase | - |
Homo sapiens |
| Gb3/CD77 synthase | - |
Homo sapiens |
| Gb3S | - |
Homo sapiens |
| lactosylceramide 4-alpha-galactosyltransferase | - |
Homo sapiens |
| lactosylceramide alpha1,4-galactosyltransferase | - |
Homo sapiens |
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