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Literature summary for 2.4.1.226 extracted from

  • Kitagawa, H.; Ujikawa, M.; Sugahara, K.
    Developmental changes in serum UDP-GlcA:chondroitin glucuronyltransferase activity (1996), J. Biol. Chem., 271, 6583-6585.
    View publication on PubMed
Search for more literature for 2.4.1.226

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
 Homo sapiens
Mn2+
-
 Rattus norvegicus
Mn2+
-
 Bos taurus
Mn2+
-
 Gallus gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan Homo sapiens
-
 UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan
-
 ?
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan Rattus norvegicus
-
 UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan
-
 ?
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan Bos taurus
-
 UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan
-
 ?
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan Gallus gallus gallus
-
 UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 fetal, newborn calf, calf, adult animals
-
Gallus gallus gallus
-
 white leghorn
-
Homo sapiens
-
-
-
Rattus norvegicus
-
 Wistar rats
-

Reaction

Reaction Comment Organism Reaction ID
UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine transfer to polymer most likely through a beta(1-3) linkage Homo sapiens
a
UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine transfer to polymer most likely through a beta(1-3) linkage Rattus norvegicus
a
UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine transfer to polymer most likely through a beta(1-3) linkage Bos taurus
a
UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine = UDP + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine transfer to polymer most likely through a beta(1-3) linkage Gallus gallus gallus
a

Source Tissue

Source Tissue Comment Organism Textmining
blood serum
-
 Homo sapiens
-
blood serum
-
 Rattus norvegicus
-
blood serum
-
 Bos taurus
-
blood serum
-
 Gallus gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 highest at the middle prenatal stage in the bovine and chicken sera, highest at the late prenatal stage in the rat serum Homo sapiens
additional information
-
 highest at the middle prenatal stage in the bovine and chicken sera, highest at the late prenatal stage in the rat serum Rattus norvegicus
additional information
-
 highest at the middle prenatal stage in the bovine and chicken sera, highest at the late prenatal stage in the rat serum Bos taurus
additional information
-
 highest at the middle prenatal stage in the bovine and chicken sera, highest at the late prenatal stage in the rat serum Gallus gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan
-
 Homo sapiens UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan
-
 ?
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan
-
 Rattus norvegicus UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan
-
 ?
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan
-
 Bos taurus UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan
-
 ?
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan
-
 Gallus gallus gallus UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-galactosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan
-
 ?
UDP-glucuronic acid + chondroitin
-
 Homo sapiens UDP + N-acetylchondrosine glucuronic acid beta(1-3)N-acetylgalactosamine
-
 ?
UDP-glucuronic acid + chondroitin
-
 Rattus norvegicus UDP + N-acetylchondrosine glucuronic acid beta(1-3)N-acetylgalactosamine
-
 ?
UDP-glucuronic acid + chondroitin
-
 Bos taurus UDP + N-acetylchondrosine glucuronic acid beta(1-3)N-acetylgalactosamine
-
 ?
UDP-glucuronic acid + chondroitin
-
 Gallus gallus gallus UDP + N-acetylchondrosine glucuronic acid beta(1-3)N-acetylgalactosamine
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 enzyme assay Homo sapiens
37
-
 enzyme assay Rattus norvegicus
37
-
 enzyme assay Bos taurus
37
-
 enzyme assay Gallus gallus gallus