Literature summary for 2.4.1.225 extracted from

Fischer, S.; Filipek-Gorniok, B.; Ledin, J.
Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling (2011), BMC Dev. Biol., 11, 53.

Search for more literature for 2.4.1.225

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	-	gene ext2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	zebrafish ext2 gene is ubiquitously expressed during zebrafish development	Danio rerio	-

Synonyms

Synonyms	Comment	Organism
EXT2	-	Danio rerio

General Information

General Information	Comment	Organism
malfunction	Fgf targeted gene expression is reduced in ext2 mutants and the remaining expression is readily inhibited by SU5402, an FGF receptor inhibitor. In the ext2 mutants, Fgf signaling is affected during nervous system development, mechanism, overview, and reduction of Fgf ligands in the mutants affects tail development. Wnt signaling is also affected in the ext2 mutants, while Hh dependent signaling is apparently unaffected in the ext2 mutants, Hh targeted gene expression is not reduced, the Hh inhibitor cyclopamine is not more affective in the mutants and Hh-dependent cell differentiation in the retina and in the myotome are normal in ext2 mutants, ext2 mutant phenotypes, overview	Danio rerio
physiological function	Ext1 and Ext2 together form a copolymerase which is responsible for the polymerization process where repeating units of N-acetylglucosamine and glucuronic acid are incorporated in the growing linear polysaccharide chain, see also EC 2.4.1.224. Gene ext2 is involved in Fgf and Wnt signaling but not in Hh signaling, ext2 is a general enhancer of Fgf target gene expression, ext2 interacts genetically with Fgf signaling during tail development, specificity for gene ext2 in signaling pathways during embryonic development, overview	Danio rerio

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Release 2023.1 (January 2023)