Literature summary for 2.4.1.225 extracted from

Busse, M.; Feta, A.; Presto, J.; Wilen, M.; Gronning, M.; Kjellen, L.; Kusche-Gullberg, M.
Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation (2007), J. Biol. Chem., 282, 32802-32810.

Search for more literature for 2.4.1.225

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK-293 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
Y419X	the EXT2 mutation results in a truncated protein	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-alpha-D-glucuronate + N-acetyl-alpha-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan	-	Homo sapiens	UDP + beta-glucuronosyl-(1-4)-N-acetyl-alpha-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-proteoglycan	-	?

Synonyms

Synonyms	Comment	Organism
exostosin	-	Homo sapiens
EXT1	EXT1 and EXT2 form a Golgi-located hetero-oligomeric complex that catalyzes the chain elongation step in heparan sulfate biosynthesis	Homo sapiens
EXT2	EXT1 and EXT2 form a Golgi-located hetero-oligomeric complex that catalyzes the chain elongation step in heparan sulfate biosynthesis	Homo sapiens
EXTL3	the EXTL proteins exhibit overlapping glycosyltransferase activities in vitro, so it is not apparent what reactions they catalyze in vivo	Homo sapiens

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Release 2023.1 (January 2023)