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Literature summary for 2.4.1.224 extracted from

  • Wang, Y.; Yang, X.; Yamagata, S.; Yamagata, T.; Sato, T.
    Involvement of Ext1 and heparanase in migration of mouse FBJ osteosarcoma cells (2013), Mol. Cell. Biochem., 373, 63-72.
    View publication on PubMed
Search for more literature for 2.4.1.224

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane Ext1 and Ext2 are type II transmembrane glycoproteins Mus musculus 5789
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the Ext1/Ext2 complex possesses higher glycosyltransferase activity than Ext1 or Ext2 alone ?
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 ?
additional information Mus musculus BALB/c the Ext1/Ext2 complex possesses higher glycosyltransferase activity than Ext1 or Ext2 alone ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 gene sext1 and ext2
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Mus musculus BALB/c
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 gene sext1 and ext2
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Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein Ext1 and Ext2 are type II transmembrane glycoproteins Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
osteosarcoma cell FBJ, highly metastatic mouse osteosarcoma FBJ-LL cells and the poorly metastatic FBJ-S1 cells are produced from a FBJ virus-induced osteosarcoma Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the Ext1/Ext2 complex possesses higher glycosyltransferase activity than Ext1 or Ext2 alone Mus musculus ?
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 ?
additional information the Ext1/Ext2 complex possesses higher glycosyltransferase activity than Ext1 or Ext2 alone Mus musculus BALB/c ?
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 ?

Synonyms

Synonyms Comment Organism
Exostosin1
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 Mus musculus
Exostosin2
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 Mus musculus
EXT1
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 Mus musculus
EXT2
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 Mus musculus

General Information

General Information Comment Organism
malfunction a reduction in either Ext1 or Ext2 can cause a reduction in heparan sulfate biosynthesis, overview. Suppression of Ext1 by siRNA in FBJ-S1 cells results in the decreased expression of heparan sulfate and enhanced motility Mus musculus
physiological function Ext1 and Ext2 are tumor suppressors. In the biosynthesis of heparan sulfate, after the attachment of a GlcNAc residue to GlcA-Gal-Gal-Xyl, Ext1 and Ext2 catalyze the subsequent elongation of glycosaminoglycans by alternately adding GlcA and GlcNAc to the end of the growing chain. Involvement of Ext1 and heparanase in migration of FBJ osteosarcoma cells, overview Mus musculus