Literature summary for 2.4.1.223 extracted from

Kim, B.T.; Kitagawa, H.; Tanaka, J.; Tamura, J.I.; Sugahara, K.
In vitro heparan sulfate polymerization: crucial roles of core protein moieties of primer substrates in addition to the EXT1-EXT2 interaction (2003), J. Biol. Chem., 278, 41618-41623.

Search for more literature for 2.4.1.223

Protein Variants

Protein Variants	Comment	Organism
additional information	activity is only detectable when enzymes EXT1 and EXT2are coexpressed, a mixture of individually expressed enzymes is inactive	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant enzymes EXT1 and EXT2, activity is only detectable when enzymes are coexpressed, a mixture of individually expressed enzymes is inactive	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	activity is only detectable when enzymes are coexpressed, a mixture of individually expressed enzymes is inactive	Homo sapiens	?	-	?
UDP-N-acetyl-D-glucosamine + alpha-thrombomodulin	55% of the activity with beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-beta-O-C2H4NHCbz	Homo sapiens	UDP + alpha-N-acetyl-D-glucosaminyl-alpha-thrombomodulin	-	?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-beta-O-Ser-Gly-Trp-Pro-Asp-Gly	-	Homo sapiens	UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-(1-3)-beta-D-galactosyl-(1-4)-beta-D-xylosyl-1-beta-O-Ser-Gly-Trp-Pro-Asp-Gly	18% of the activity with beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-beta-O-C2H4NHCbz	?
UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-beta-O-C2H4NHCbz	-	Homo sapiens	UDP + alpha-N-acetyl-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-beta-O-C2H4NHCbz	-	?
UDP-N-acetyl-D-glucosamine + glypican-1	30% of the activity with beta-D-glucuronosyl-(1-3)-beta-D-galactosyl-1-beta-O-C2H4NHCbz	Homo sapiens	UDP + alpha-N-acetyl-D-glucosaminyl-glypican-1	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)