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Literature summary for 2.4.1.222 extracted from

  • Gu, W.; Xu, W.; Ding, T.; Guo, X.
    Fringe controls naive CD4(+)T cells differentiation through modulating notch signaling in asthmatic rat models (2012), PLoS ONE, 7, e47288.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.222

Protein Variants

Protein Variants Comment Organism
additional information gene silencing by Rfng-specific siRNA and overexpression of Lfng or Mfng in asthmatic CD4+ T lymphocytes. Downregulation of Rfng and overexpression of Lfng or Mfng enhance Th1 cytokines but suppress Th2 cytokine production, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[Notch]-fucose + UDP-alpha-D-N-acetylglucosamine Rattus norvegicus
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 [Notch]-(3-O-beta-D-N-acetylglucosaminyl)fucose + UDP
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 three Fringe homologues Lfng, Mfng, and Rfng
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Source Tissue

Source Tissue Comment Organism Textmining
T-lymphocyte expression levels of three Fringe homologues in naive CD4+T cells in asthmatic rats, overview. Radical Fringe (Rfng) is highly expressed, whereas both Lunatic Fringe (Lfng) and Manic Fringe (Mfng) are expressed at low levels Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[Notch]-fucose + UDP-alpha-D-N-acetylglucosamine
-
 Rattus norvegicus [Notch]-(3-O-beta-D-N-acetylglucosaminyl)fucose + UDP
-
 ?

Synonyms

Synonyms Comment Organism
Fringe
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 Rattus norvegicus
LFNG
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 Rattus norvegicus
Lunatic Fringe
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 Rattus norvegicus
Manic fringe
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 Rattus norvegicus
MFng
-
 Rattus norvegicus
O-fucose-beta1,3-N-acetylglucosaminyltransferase
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 Rattus norvegicus
Radical Fringe
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 Rattus norvegicus
Rfng
-
 Rattus norvegicus

General Information

General Information Comment Organism
malfunction Lfng overexpression results in significantly decreased Th2 cytokine production in asthma, which is the same effect as the gamma-secretase inhibitor GSI treatment alone, but has an increased effect on Th1 cytokines than GSI treatment Rattus norvegicus
physiological function Fringe modulates Notch receptor expression and promotes the Notch signaling pathway through receptor-ligand binding, essential role of Fringe, overview. Notch signaling is more activated in asthmatic naive CD4+T cells than in control cells, and Lfng, but not Mfng or Rfng, partly inhibit Notch signaling in asthmatic naive CD4+T lymphocytes Rattus norvegicus