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Literature summary for 2.4.1.222 extracted from

  • Visan, I.; Yuan, J.S.; Liu, Y.; Stanley, P.; Guidos, C.J.
    Lunatic Fringe enhances competition for delta-like Notch ligands but does not overcome defective pre-TCR signaling during thymocyte beta-selection in vivo (2010), J. Immunol., 185, 4609-4617.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
Lfng overexpression in transgenic mouse model Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 gene lfng
-

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
 Mus musculus
-
thymocyte
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
LFNG
-
 Mus musculus
Lunatic Fringe
-
 Mus musculus

General Information

General Information Comment Organism
malfunction Lfng modification of EGF12 in the Notch1 ligand-binding domain contributes to, but is not solely responsible for, the cell-nonautonomous inhibition of T cell development caused by transgenic Lfng expression in double-positive thymocytes. O-fucose site in the Notch1 ligand binding domain is partly responsible for the effects of Lfng overexpression Mus musculus
physiological function Notch1 activation by Delta-like Notch ligands is essential to induce T cell commitment and to suppress B cell development from thymus-seeding progenitors. Thymus-seeding progenitor competition for Delta-like ligand DL4 is critically regulated by Lunatic Fringe, which glycosylates epidermal growth factor repeats in the Notch1 extracellular domain to enhance binding avidity for Delta-like ligands. Notch1 activation is also essential for the process of beta-selection, which drives TCRbeta+ CD4/CD8 double-negative 3 precursors to proliferate and generate a large pool of CD4/CD8 double-positive thymocytes. Lunatic Fringe enhances competition for delta-like Notch ligands but does not overcome defective pre-TCR signaling during thymocyte beta-selection in vivo, importance of Lfng-Notch1 interactions in regulating competition of preselection and postselection DN3 thymocytes for DL ligands in vivo, overview. Transgenic Lfng confers a competitive advantage to wild-type but not Rag2-/- DN3 thymocytes. Lfng improves the competitive fitness of Lck-deficient and Ptcra-deficient DN3beta thymocytes Mus musculus