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Literature summary for 2.4.1.222 extracted from

  • Xu, K.; Nieuwenhuis, E.; Cohen, B.; Wang, W.; Canty, A.; Danska, J.; Coultas, L.; Rossant, J.; Wu, M.; Piscione, T.; Nagy, A.; Gossler, A.; Hicks, G.; Hui, C.; Henkelman, R.; Yu, L.; Sled, J.; Gridley, T.; Egan, S.
    Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis (2010), Am. J. Physiol. Lung Cell Mol. Physiol., 298, L45-L56.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Mus musculus O09010 gene lfng
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Source Tissue

Source Tissue Comment Organism Textmining
lung Lfng is expressed in the distal lung during saccular development Mus musculus
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myofibroblast
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 Mus musculus
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Synonyms

Synonyms Comment Organism
LFNG
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 Mus musculus
Lunatic Fringe
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 Mus musculus

General Information

General Information Comment Organism
malfunction deletion of gene lfng impairs myofibroblast differentiation and alveogenesis, alveolar developmental defect in Lfng mutants with altered elastogenesis and collagen deposition in Lfng mutant lungs, phenotype, overview Mus musculus
physiological function Lunatic Fringe, Lfng, is a beta1-3 N-acetylglucosamine transferase that modifies Notch receptors to facilitate their activation by Delta-like (Dll1/4) ligands, Lfng functions to enhance Notch-dependent induction of myofibroblast differentiation during embryonic lung development in the mouse Mus musculus