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Literature summary for 2.4.1.222 extracted from

  • Nikolaou, N.; Watanabe-Asaka, T.; Gerety, S.; Distel, M.; Koester, R.W.; Wilkinson, D.G.
    Lunatic fringe promotes the lateral inhibition of neurogenesis (2009), Development, 136, 2523-2533.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Danio rerio
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Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell Lfng is required cell autonomously in neural epithelial cells to limit the amount of neurogenesis and to maintain progenitors Danio rerio
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hindbrain isoform lunatic fringe Lfng is expressed by progenitors in neurogenic regions and downregulated in cells that have initiated neuronal differentiation Danio rerio
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Synonyms

Synonyms Comment Organism
LFNG
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Danio rerio

Expression

Organism Comment Expression
Danio rerio the expression of Lfng does not require Notch activity, but rather is regulated downstream of proneural genes that are widely expressed by neural progenitors additional information

General Information

General Information Comment Organism
physiological function Lfng is required cell autonomously in neural epithelial cells to limit the amount of neurogenesis and to maintain progenitors. Lfng is not required for the role of Notch in interneuronal fate choice, which is mediated by Notch1a. The expression of Lfng does not require Notch activity, but rather is regulated downstream of proneural genes that are widely expressed by neural progenitors Danio rerio