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Literature summary for 2.4.1.222 extracted from

  • Okajima, T.; Xu, A.; Irvine, K.D.
    Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe (2003), J. Biol. Chem., 278, 42340-42345.
    View publication on PubMed
Search for more literature for 2.4.1.222

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in S2 cells Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Notch + UDP-D-GlcNAc Drosophila melanogaster enzyme completely inhibits binding of Notch protein to its serrate ligands by capping of O-fucose sites, regulation of enzyme activity via expression level in correspondance to the expression level of protein O-fucosyltransferase beta-D-glucosaminyl-Notch + UDP
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 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Notch + UDP-D-GlcNAc enzyme completely inhibits binding of Notch protein to its serrate ligands by capping of O-fucose sites, regulation of enzyme activity via expression level in correspondance to the expression level of protein O-fucosyltransferase Drosophila melanogaster beta-D-glucosaminyl-Notch + UDP
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 ?
Notch + UDP-D-GlcNAc Notch protein is O-fucosylated at a serine or threonine residue in the epidermal growth factor-like domain Drosophila melanogaster beta-D-glucosaminyl-Notch + UDP
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 ?

Synonyms

Synonyms Comment Organism
FNG
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 Drosophila melanogaster

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Drosophila melanogaster

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Drosophila melanogaster