Literature summary for 2.4.1.222 extracted from

Panin, V.M.; Shao, L.; Lei, L.; Moloney, D.J.; Irvine, K.D.; Haltiwanger, R.S.
Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe (2002), J. Biol. Chem., 277, 29945-29952.

Search for more literature for 2.4.1.222

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Drosophila S2 cells	Drosophila melanogaster
Manic Fringe stable expressed in Chinese hamster ovary Lec1 cells	Mammalia

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-
Mammalia	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
O-fucose residues on Delta Notch ligand + UDP-GlcNAc	in vitro	Drosophila melanogaster	GlcNAc-beta-1,3-fucitol-Delta Notch	-	?
O-fucose residues on Delta Notch ligand + UDP-GlcNAc	rat Delta1 ligand, exogenous expressed in Chinese hamster ovary Lec1 cells, experiment in vivo	Mammalia	GlcNAc-beta-1,3-fucitol-Delta Notch	-	?
O-fucose residues on Jagged1 Notch ligand + UDP-GlcNAc	human Jagged1 ligand, exogenous expressed in Chinese hamster ovary Lec1 cells, experiment in vivo	Mammalia	GlcNAc-beta1,3-fucitol-Jagged1 Notch	-	?
O-fucose residues on Serrate Notch ligand + UDP-GlcNAc	in vitro	Drosophila melanogaster	?	-	?
UDP-beta-D-GlcNAc + fucosyl-protein	-	Drosophila melanogaster	UDP + O-beta-D-GlcNAc-fucosyl-protein	-	?
UDP-beta-D-GlcNAc + fucosyl-protein	-	Mammalia	UDP + O-beta-D-GlcNAc-fucosyl-protein	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
29	-	enzyme assay	Drosophila melanogaster

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Release 2023.1 (January 2023)