Literature summary for 2.4.1.222 extracted from

Bruckner, K.; Perez, L.; Clausen, H.; Cohen, S.
Glycosyltransferase activity of Fringe modulates Notch-Delta interactions (2000), Nature, 406, 411-415.

Search for more literature for 2.4.1.222

Cloned(Commentary)

Cloned (Comment)	Organism
Notch alone or Fringe alone expressed in Drosophila SL2 cells or Notch and Fringe co-expressed in Drosophila SL2 cells	Drosophila melanogaster

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	microsomal fraction enriched for Golgi membrane	Drosophila melanogaster	-	-

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
UDP-beta-D-GlcNAc + PCQNGGS(O-beta-L-fucosyl)-CKDQL = UDP + PCQNGGS(O-D-GlcNAcbeta(1-3)-L-Fucbeta)-CKDQL	co-expressing of Notch and Fringe in Drosophila SL2 cells results in an increase of binding of ligand Delta to Notch	Drosophila melanogaster	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-fucose + GlcNAc	-	Drosophila melanogaster	GlcNAc-beta-1,3-fucitol	-	?
UDP-beta-D-GlcNAc + fucosyl-protein	-	Drosophila melanogaster	UDP + O-beta-D-GlcNAc-fucosyl-protein	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	enzyme assay	Drosophila melanogaster

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Release 2023.1 (January 2023)