Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | presomitic mesoderm | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Pofut1 | - |
Mus musculus |
protein O-fucosyltransferase 1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | Pofut1-null mouse shows a similar phenotype to the RBP-Jk null mouse. Cardiac development in the Pofut1-/- mice is severely affected in valve formation, which is characterized in the lack of mesenchymal cells as seen in RBP-Jk null embryos and embryonic development is arrested at E9.0. Pofut1-null cells do not possess normally localized Notch1 receptors. Abnormal accumulation of the Notch1 receptor in the endoplasmic reticulum and cytoplasm in Pofut1-null mouse embryos | Mus musculus |
physiological function | Pofut1 is required for Notch signaling upstream of NICD1 | Mus musculus |