Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Mus musculus | - |
intestine | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Pofut1 | - |
Mus musculus |
protein O-fucosyltransferase 1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | Pofut1 deletion inactivates Notch signaling, giving rise to smaller but viable mice. Dysplastic foci in Pofut1-deficient small intestine with occasional progression to tumor formation. Inactivation of Pofut1 leads to intestinal inflammation. Mucus hypersecretion upon Pofut1 inactivation is accompanied by alteration of the mucus-associated flora, which likely contributes to the development of enterocolitis | Mus musculus |