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Literature summary for 2.4.1.221 extracted from

  • Guilmeau, S.; Flandez, M.; Bancroft, L.; Sellers, R.; Tear, B.; Stanley, P.; Augenlicht, L.
    Intestinal deletion of Pofut1 in the mouse inactivates notch signaling and causes enterocolitis (2008), Gastroenterology, 135, 849-860.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
colon
-
Mus musculus
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intestine
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Mus musculus
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Synonyms

Synonyms Comment Organism
Pofut1
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Mus musculus
protein O-fucosyltransferase 1
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Mus musculus

General Information

General Information Comment Organism
malfunction Pofut1 deletion inactivates Notch signaling, giving rise to smaller but viable mice. Dysplastic foci in Pofut1-deficient small intestine with occasional progression to tumor formation. Inactivation of Pofut1 leads to intestinal inflammation. Mucus hypersecretion upon Pofut1 inactivation is accompanied by alteration of the mucus-associated flora, which likely contributes to the development of enterocolitis Mus musculus