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Literature summary for 2.4.1.22 extracted from
- Comparison of the closed conformation of the beta1,4-galactosyltransferase-1 (beta4Gal-T1) in the presence and absence of alpha-lactalbumin (LA) (2003), J. Biomol. Struct. Dyn., 21, 1-8.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| wild-type and mutant enzyme in closed conformation induced by UDP-galactose, X-ray diffraction structure determination and analysis at 2.3 A resolution, re-refinement or previously determined crystal structures of enzyme complexed with different substrates and Mn2+, overview | Bos taurus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C342T | determination and analysis of the closed conformation crystal structure of enzyme mutant in complex with UDP-galactose | Bos taurus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | required | Bos taurus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | molecular interaction with different donor substrates, overview, the enzyme undergoes transition from open to close conformation upon binding of donor or acceptor substrate, overview | Bos taurus | ? | - |
? | |
| UDP-galactose + D-glucose | in presence of alpha-lactalbumin | Bos taurus | UDP + lactose | - |
? | |
| UDP-galactose + N-acetyl-D-glucosamine | - |
Bos taurus | UDP + D-galactosyl(1-4)beta-N-acetyl-D-glucosamine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| beta1,4-galactosyltransferase-1 | - |
Bos taurus |
| beta4Gal-T1 | - |
Bos taurus |
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Release 2023.1 (January 2023)
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