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Literature summary for 2.4.1.214 extracted from

  • Martinez, M.; Joffraud, M.; Giraud, S.; Baisse, B.; Bernimoulin, M.P.; Schapira, M.; Spertini, O.
    Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII (2005), J. Biol. Chem., 280, 5378-5390.
    View publication on PubMed
Search for more literature for 2.4.1.214

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens FucT-IV and FucT-VII are responsible for generation of sialylated Lewis X, i.e. sLex, FucT-VII being the major enzyme form in selectin ligand activity regulating leukocyte recruitment and lymphocyte homing into lymph nodes, FucT-IV and FucT-VII are both involved in conferring L-, P- and E-selectin binding activities to P-selectin glycoprotein ligand-1, i.e. PSGL-1, in humans, overview, FucT-IV and FucT-VII show cooperation in recruitment of selectin-expressing cells on PSGL-1 and in regulating cell rolling velocity and stability ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
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 Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 FucT-IV and FucT-VII regulated E-, L-, and P-selectin-dependent rolling of cells, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information FucT-IV and FucT-VII are responsible for generation of sialylated Lewis X, i.e. sLex, FucT-VII being the major enzyme form in selectin ligand activity regulating leukocyte recruitment and lymphocyte homing into lymph nodes, FucT-IV and FucT-VII are both involved in conferring L-, P- and E-selectin binding activities to P-selectin glycoprotein ligand-1, i.e. PSGL-1, in humans, overview, FucT-IV and FucT-VII show cooperation in recruitment of selectin-expressing cells on PSGL-1 and in regulating cell rolling velocity and stability Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
alpha1,3-fucosyltransferase
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 Homo sapiens
FucT-IV
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 Homo sapiens
FucT-VII
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 Homo sapiens