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Literature summary for 2.4.1.212 extracted from

  • Li, Y.; Liang, J.; Yang, T.; Monterrosa Mena, J.; Huan, C.; Xie, T.; Kurkciyan, A.; Liu, N.; Jiang, D.; Noble, P.W.
    Hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis (2016), Matrix Biol., 55, 35-48.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.212

Application

Application Comment Organism
medicine targeting HAS2 to induce fibroblast senescence can be an attractive approach to resolve tissue fibrosis Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
gene HAS2, real-time PCR enzyme expression Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information enzyme downregulation by HAS2 siRNA transfection Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus P70312 isozyme HAS2
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast HAS2 is suppressed in senescent fibroblasts, real time PCR enzyme expresion in fibrotic and senescent fibroblasts Mus musculus
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lung
-
 Mus musculus
-
mesenchymal cell
-
 Mus musculus
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myofibroblast
-
 Mus musculus
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Synonyms

Synonyms Comment Organism
Has2
-
 Mus musculus
hyaluronan synthase 2
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus isozyme HAS2 is suppressed in senescent fibroblasts down

General Information

General Information Comment Organism
malfunction downregulation of HAS2 initiates and regulates fibroblast senescence through a p27-CDK2-SKP2 pathway. Deletion of HAS2 in mouse mesenchymal cells increases the cellular senescence of fibroblasts in bleomycin-induced mouse lung fibrosis in vivo. Overexpression of HAS2 in mesenchymal cells promotes an invasive phenotype resulting in severe fibrosis and downregulation of HAS2 promotes resolution. HAS2 deficiency leads to embryonic lethality. Downregulation of HAS2 increases p27 protein stability. p27 inhibits cell proliferation by regulating CDK2 activity. HAS2 deletion enhances cell stress responses. Phenotypes, detailed overview Mus musculus
physiological function hyaluronan synthase 2 regulates fibroblast senescence in pulmonary fibrosis. Senescence is implicated in development, cancer, and tissue fibrosis. The chronic inflammation caused by cellular senescence may be related to the pathogenesis of various chronic diseases. Isozyme HAS2 may be a critical regulator of the fate of pulmonary fibrosis. Isozyme HAS2 is the major isoform responsible for hyaluronan production in mesenchymal cells Mus musculus