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Literature summary for 2.4.1.212 extracted from

  • Kultti, A.; Pasonen-Seppaenen, S.; Jauhiainen, M.; Rilla, K.J.; Kaernae, R.; Pyoeriae, E.; Tammi, R.H.; Tammi, M.I.
    4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3 (2009), Exp. Cell Res., 315, 1914-1923.
    View publication on PubMed
Search for more literature for 2.4.1.212

Organism

Organism UniProt Comment Textmining
Homo sapiens O00219 isoform HAS3
-
Homo sapiens Q92819 isoform HAS2
-

Source Tissue

Source Tissue Comment Organism Textmining
A-2058 cell
-
 Homo sapiens
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MCF-7 cell
-
 Homo sapiens
-
MDA-MB-361 cell
-
 Homo sapiens
-
SKOV-3 cell
-
 Homo sapiens
-
UT-SCC-118 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
hyaluronan synthase 3
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens HAS2 is the major isoenzyme in MCF-7 cells. The mRNA expression is lowered by 4-methylumbelliferone by 81% in MCF-7 cells, and by 88% in A2058 cells. Both HAS substrate and HAS2 and/or HAS3 mRNA are targeted by 4-methylumbelliferone. The reduction of hyaluronan caused by 4-methylumbelliferone is associated with a significant inhibition of cell migration, proliferation and invasion down
Homo sapiens in MDA-MB-361, A2058 and SKOV-3 cells, treatment with 4-methylumbelliferone decreases HAS3 mRNA by 84-60%. The reduction of hyaluronan caused by 4-methylumbelliferone is associated with a significant inhibition of cell migration, proliferation and invasion down

General Information

General Information Comment Organism
physiological function the reduction of hyaluronan caused by enzyme downregulation through 4-methylumbelliferone is associated with a significant inhibition of cell migration, proliferation and invasion Homo sapiens