Literature summary for 2.4.1.212 extracted from

Campo, G.M.; Avenoso, A.; Campo, S.; DAscola, A.; Traina, P.; Calatroni, A.
Effect of cytokines on hyaluronan synthase activity and response to oxidative stress by fibroblasts (2009), Br. J. Biomed. Sci., 66, 28-36.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O00219	isoform HAS3	-
Homo sapiens	Q92819	isoform HAS2	-
Homo sapiens	Q92839	isoform HAS1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
DPK-SKDF-H cell	-	Homo sapiens	-
DPK-SKDF-H cell	skin dermal fibroblast cell	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	transforming grwoth factor 1beta significantly inhibits HAS3 expression and protein formation	down
Homo sapiens	both tumor necrosis factor TNFalpha and interferon INFgamma significantly induce HAS3 expression	up
Homo sapiens	both tumor necrosis factor TNFalpha and transforming growth factor 1beta significantly increase HAS1 expression and protein synthesis. Exposure to reactive oxygen species results in increased gene expression and protein formation of HAS1	up
Homo sapiens	both tumor necrosis factor TNFalpha and transforming growth factor 1beta significantly increase HAS2 expression and protein synthesis. Exposure to reactive oxygen species results in increased gene expression and protein formation of HAS2	up

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Release 2023.1 (January 2023)