Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.212 extracted from

  • Bourguignon, L.Y.; Gilad, E.; Peyrollier, K.
    Heregulin-mediated ErbB2-ERK signaling activates hyaluronan synthases leading to CD44-dependent ovarian tumor cell growth and migration (2007), J. Biol. Chem., 282, 19426-19441.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ERK heregulin-mediated HAS isozyme phosphorylation/activation Homo sapiens

Application

Application Comment Organism
medicine heregulin activation of ErbB2-ERK signaling modulates HAS phosphorylation/activation and hyaluronan production leading to CD-44-mediated oncogenic events and ovarian cancer progression Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
the human HAS2 expression plasmid is prepared by inserting its coding sequence into the vector pcDNA 3.1/CT-GFP-TOPO Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
AG825 ErbB2 inhibitor, blocks the heregulin-mediated HAS isozyme phosphorylation/activation; ErbB2 inhibitor, blocks the heregulin-mediated HAS isozyme phosphorylation/activation; ErbB2 inhibitor, blocks the heregulin-mediated HAS isozyme phosphorylation/activation Homo sapiens
siRNA
-
Homo sapiens
thiazolidinedione ERK inhibitor, blocks the heregulin-mediated HAS isozyme phosphorylation/activation; ERK inhibitor, blocks the heregulin-mediated HAS isozyme phosphorylation/activation; ERK inhibitor, blocks the heregulin-mediated HAS isozyme phosphorylation/activation Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
determined by SDS-PAGE and Western Blot analysis Homo sapiens
62000
-
determined by SDS-PAGE and Western Blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan] Homo sapiens
-
UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
-
?
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan] Homo sapiens
-
UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q92819 sequence used for preparation of siRNA
-
Homo sapiens Q92839 sequence used for preparation of siRNA
-
Homo sapiens Q96RV2 sequence used for preparation of siRNA
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein ERK-mediated phosphorylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-
ovary cancer cell
-
Homo sapiens
-
SKOV-3 cell SKOV-3.ipl cell, the cell line is established from ascites that developed in a nu/nu mouse given an intraperitoneal injection of SK-OV-3 human ovarian carcinoma cell line Homo sapiens
-
SKOV-3 cell the SK-OV-3.ipl cell line is established from ascites that developed in a nu/nu mouse given an intraperitoneal injection of SK-OV-3 human ovarian carcinoma cell line Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000000062
-
HAS activity, HAS1siRNA + HAS2siRNA + HAS3siRNA treatment, plus heregulin Homo sapiens
0.0000000092
-
HAS activity, HAS1siRNA + HAS2siRNA + HAS3siRNA treatment Homo sapiens
0.000000017
-
HAS activity, HAS2siRNA treatment Homo sapiens
0.0000000175
-
HAS activity, HAS1siRNA treatment Homo sapiens
0.0000000188
-
HAS activity, HAS3siRNA treatment Homo sapiens
0.0000000222
-
HAS activity, AG825 treatment Homo sapiens
0.0000000227
-
HAS activity, HAS2siRNA treatment, plus heregulin Homo sapiens
0.000000023
-
HAS activity, thiazolidinedione treatment Homo sapiens
0.0000000233
-
HAS activity, no treatment, control Homo sapiens
0.0000000237
-
HAS activity, scrambled sequence treatment, control Homo sapiens
0.0000000248
-
HAS activity, HAS1siRNA treatment, plus heregulin Homo sapiens
0.000000025
-
HAS activity, HAS3siRNA treatment, plus heregulin Homo sapiens
0.0000000257
-
HAS activity, AG825 treatment, plus heregulin Homo sapiens
0.0000000263
-
HAS activity, thiazolidinedione treatment, plus heregulin Homo sapiens
0.0000000583
-
HAS activity, scrambled sequence treatment, control, plus heregulin Homo sapiens
0.0000000627
-
HAS activity, no treatment, control, plus heregulin Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
-
Homo sapiens UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]
-
?
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
-
Homo sapiens UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]
-
?

Synonyms

Synonyms Comment Organism
HAS1
-
Homo sapiens
Has2
-
Homo sapiens
Has3
-
Homo sapiens
hyaluronan synthase
-
Homo sapiens