Literature summary for 2.4.1.212 extracted from

Campo, G.M.; Avenoso, A.; Campo, S.; DAscola, A.; Ferlazzo, A.M.; Calatroni, A.
Differential effect of growth factors on hyaluronan synthase gene expression in fibroblasts exposed to oxidative stress (2007), Biochemistry, 72, 974-982.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Epidermal growth factor	EGF	Homo sapiens
platelet derived growth factor BB	PDGF-BB	Homo sapiens
Transforming growth factor	TGF-1beta	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]	Homo sapiens	-	UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]	-	?
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]	Homo sapiens	-	UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
skin fibroblast	type DPK-SKDF-H	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]	-	Homo sapiens	UDP + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-[nascent hyaluronan]	-	?
UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]	-	Homo sapiens	UDP + N-acetyl-beta-D-glucosaminyl-(1-4)-beta-D-glucuronosyl-(1-3)-N-acetyl-beta-D-glucosaminyl-(1-4)-[nascent hyaluronan]	-	?

Synonyms

Synonyms	Comment	Organism
HAS	three isoforms, HAS1, HAS2, HAS3	Homo sapiens
hyaluronan synthase	-	Homo sapiens

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Release 2023.1 (January 2023)