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Literature summary for 2.4.1.212 extracted from

  • Tlapak-Simmons, V.L.; Baron, C.A.; Gotschall, R.; Haque, D.; Canfield, W.M.; Weigel, P.H.
    Hyaluronan biosynthesis by class I streptococcal hyaluronan synthases occurs at the reducing end (2005), J. Biol. Chem., 280, 13012-13018.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of His-tagged enzyme in Escherichia coli Streptococcus dysgalactiae subsp. equisimilis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Streptococcus dysgalactiae subsp. equisimilis
Mg2+
-
Streptococcus pyogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate Streptococcus dysgalactiae subsp. equisimilis addition of monosaccharides to the reducing end to form a linear heteropolysaccharide chain [beta-N-acetyl-D-glucosaminyl(1-4)beta-D-glucuronosyl(1-3)]n + UDP
-
?
UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate Streptococcus pyogenes addition of monosaccharides to the reducing end to form a linear heteropolysaccharide chain [beta-N-acetyl-D-glucosaminyl(1-4)beta-D-glucuronosyl(1-3)]n + UDP
-
?

Organism

Organism UniProt Comment Textmining
Streptococcus dysgalactiae subsp. equisimilis
-
class I enzyme
-
Streptococcus pyogenes
-
class I enzyme
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged enzyme from Escherichia coli by nickel affinity chromatography Streptococcus dysgalactiae subsp. equisimilis

Reaction

Reaction Comment Organism Reaction ID
UDP-N-acetyl-alpha-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] addition of monosaccharides to the reducing end to form a linear heteropolysaccharide chain Streptococcus dysgalactiae subsp. equisimilis
UDP-N-acetyl-alpha-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan] addition of monosaccharides to the reducing end to form a linear heteropolysaccharide chain Streptococcus pyogenes

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information determination of polymer synthesis progression direction, overview Streptococcus dysgalactiae subsp. equisimilis ?
-
?
additional information determination of polymer synthesis progression direction, overview Streptococcus pyogenes ?
-
?
UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate addition of monosaccharides to the reducing end to form a linear heteropolysaccharide chain Streptococcus dysgalactiae subsp. equisimilis [beta-N-acetyl-D-glucosaminyl(1-4)beta-D-glucuronosyl(1-3)]n + UDP
-
?
UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate addition of monosaccharides to the reducing end to form a linear heteropolysaccharide chain Streptococcus pyogenes [beta-N-acetyl-D-glucosaminyl(1-4)beta-D-glucuronosyl(1-3)]n + UDP
-
?
UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate addition of monosaccharides to the reducing end to form a linear heteropolysaccharide chain Streptococcus dysgalactiae subsp. equisimilis [beta-N-acetyl-D-glucosaminyl(1-4)beta-D-glucuronosyl(1-3)]n + UDP product chain length depends on reaction conditions, overview ?
UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate addition of monosaccharides to the reducing end to form a linear heteropolysaccharide chain Streptococcus pyogenes [beta-N-acetyl-D-glucosaminyl(1-4)beta-D-glucuronosyl(1-3)]n + UDP product chain length depends on reaction conditions, overview ?

Synonyms

Synonyms Comment Organism
HASs
-
Streptococcus dysgalactiae subsp. equisimilis
HASs
-
Streptococcus pyogenes
More enzyme belongs to class I of hyaluronan synthases Streptococcus dysgalactiae subsp. equisimilis
More enzyme belongs to class I of hyaluronan synthases Streptococcus pyogenes

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at Streptococcus dysgalactiae subsp. equisimilis
30
-
assay at Streptococcus pyogenes

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Streptococcus dysgalactiae subsp. equisimilis
7.5
-
assay at Streptococcus pyogenes