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Literature summary for 2.4.1.201 extracted from
- A method for determination of UDP-GlcNAc: GlcNAcbeta1-6(GlcNAcbeta1-2)Manalpha1-R [GlcNAc to Man] beta1-4N-acetylglucosaminyltransferase VI activity (2013), Methods Mol. Biol., 1022, 299-305.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | activates | Homo sapiens |  |
| Mg2+ | activates | Homo sapiens | |
| Mn2+ | required, best divalent cation | Homo sapiens | |
| additional information | divalent cation-dependent enzyme activity, maximal activity with Mn2+. Co2+ and Mg 2+ can partially substitute for Mn2+ | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-D-glucosamine + 2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-R | Homo sapiens | - |
UDP + 2,4,6-tris(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-R | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | evaluation of a highly sensitive method for determination of the activity of GnT VI using a fl uorescently labeled tetraantennary oligosaccharide as an acceptor substrate. GnT VI stringently requires beta1,6-N-acetylglucosaminylation on the Manalpha1-6 arm (GnT V product, EC 2.4.1.155) as an acceptor substrate. Agalacto-triantennary oligosaccharide (GnT V product) can also be used as an alternate substrate | Homo sapiens | ? | - |
? | |
| UDP-N-acetyl-D-glucosamine + 2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-R | - |
Homo sapiens | UDP + 2,4,6-tris(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-R | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GnT VI | - |
Homo sapiens |
| UDP-GlcNAc: GlcNAcbeta1-6(GlcNAcbeta1-2)Manalpha1-R [GlcNAc to Man] beta1-4N-acetylglucosaminyltransferase VI | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | six different N-acetylglucosaminyltransferases (GnTs) I through VI are involved in the GlcNAc branching of the core | Homo sapiens |
| physiological function | the enzyme contributes to the surface expression of CD133 through the processing of multiantennary N -linked glycans on CD133 | Homo sapiens |
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Release 2023.1 (January 2023)
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