Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | activates | Homo sapiens | |
Mg2+ | activates | Homo sapiens | |
Mn2+ | required, best divalent cation | Homo sapiens | |
additional information | divalent cation-dependent enzyme activity, maximal activity with Mn2+. Co2+ and Mg 2+ can partially substitute for Mn2+ | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-glucosamine + 2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-R | Homo sapiens | - |
UDP + 2,4,6-tris(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-R | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | evaluation of a highly sensitive method for determination of the activity of GnT VI using a fl uorescently labeled tetraantennary oligosaccharide as an acceptor substrate. GnT VI stringently requires beta1,6-N-acetylglucosaminylation on the Manalpha1-6 arm (GnT V product, EC 2.4.1.155) as an acceptor substrate. Agalacto-triantennary oligosaccharide (GnT V product) can also be used as an alternate substrate | Homo sapiens | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + 2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-R | - |
Homo sapiens | UDP + 2,4,6-tris(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl-R | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GnT VI | - |
Homo sapiens |
UDP-GlcNAc: GlcNAcbeta1-6(GlcNAcbeta1-2)Manalpha1-R [GlcNAc to Man] beta1-4N-acetylglucosaminyltransferase VI | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | six different N-acetylglucosaminyltransferases (GnTs) I through VI are involved in the GlcNAc branching of the core | Homo sapiens |
physiological function | the enzyme contributes to the surface expression of CD133 through the processing of multiantennary N -linked glycans on CD133 | Homo sapiens |