Literature summary for 2.4.1.183 extracted from

Yoshimi, A.; Sano, M.; Inaba, A.; Kokubun, Y.; Fujioka, T.; Mizutani, O.; Hagiwara, D.; Fujikawa, T.; Nishimura, M.; Yano, S.; Kasahara, S.; Shimizu, K.; Yamaguchi, M.; Kawakami, K.; Abe, K.
Functional analysis of the alpha-1,3-glucan synthase genes agsA and agsB in Aspergillus nidulans: agsB is the major alpha-1,3-glucan synthase in this fungus (2013), PLoS ONE, 8, e54893.

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Cloned(Commentary)

Cloned (Comment)	Organism
genes agsA and agsB, expression analysis	Aspergillus nidulans

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of several mutant strains in Aspergillus nidulans by gene replacement: agsA disruption, agsB disruption, and double-disruption strains, as well asl CagsB strains in which agsB expression is controlled by the inducible alcA promoter, with or without the agsA-disrupting mutation. The agsA disruption strains do not show markedly different phenotypes from the wild-type strain. The agsB disruption strains forms dispersed hyphal cells under liquid culture conditions, regardless of the agsA genetic background. Dispersed hyphal cells are also observed in liquid culture of the CagsB strains when agsB expression is repressed, whereas these strains grow normally in plate culture even under the agsB-repressed conditions. Phenotypes, overview	Aspergillus nidulans

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cell wall	-	Aspergillus nidulans	5618	-

Organism

Organism	UniProt	Comment	Textmining
Aspergillus nidulans	Q5B0P5	i.e. Emericella nidulans, genes agsA and agsB	-
Aspergillus nidulans ATCC 38163	Q5B0P5	i.e. Emericella nidulans, genes agsA and agsB	-

Synonyms

Synonyms	Comment	Organism
AGS	-	Aspergillus nidulans

General Information

General Information	Comment	Organism
malfunction	alpha-1,3-glucan is the main component of the alkali-soluble cell wall fraction in the wild-type and agsA disruption strains, but almost no alpha-1,3-glucan is found in the alkali-soluble fraction derived from either the agsB disruption strain or the CagsB strain under the agsB-repressed conditions, regardless of the agsA genetic background. Hyphal morphology of the control and agsB disruption strains, overview	Aspergillus nidulans
additional information	expression profiles of genes involved in cell wall biosynthesis. Levels of transcription of several cell wall-related genes (gelA, chsA, and gfaA) are significantly upregulated in the agsB disruption strain, transcription of gelB and csmB is significantly downregulated in the disruptant. In the CagsB strain, the expression of genes agsA, fksA, gelA, chsA, and gfaA is significantly upregulated under the agsB-repressing conditions, as is the case in the agsB disruption strain for all except fksA. In contrast, under the agsB-inducing conditions, the expression levels of fksA, gelB, chsD, and gfaA are significantly reduced in the CagsB strain, gene csmA is significantly upregulated under these conditions	Aspergillus nidulans
physiological function	the enzyme is involved in the cell wall biogenesis. Alteration of the alpha-1,3-glucan amount is counterbalanced by alterations in the amount of another cell wall component such as beta-1,3-glucan or chitin	Aspergillus nidulans

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Release 2023.1 (January 2023)