Literature summary for 2.4.1.183 extracted from

Maubon, D.; Park, S.; Tanguy, M.; Huerre, M.; Schmitt, C.; Prevost, M.C.; Perlin, D.S.; Latge, J.P.; Beauvais, A.
AGS3, an a(1-3)glucan synthase gene family member of Aspergillus fumigatus, modulates mycelium growth in the lung of experimentally infected mice (2006), Fungal Genet. Biol., 43, 366-375.

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Cloned(Commentary)

Cloned (Comment)	Organism
Escherichia coli strain DH5alpha	Aspergillus fumigatus

Protein Variants

Protein Variants	Comment	Organism
additional information	deltaags3, with a non-functional, disrupted AGS3 gene. The cell wall composition of the mycelium or the conidia of the deltaags3 mutant and the wild type strain does not present any qualitive or quantitive differences. The dense outer layer surrounding the conidial cell wall that contains melanin is 2times thicker in the deltaags3 mutants than in the wild type. Deletion of AGS1 results in a 2.8 and 1.9fold increase in the expression of AGS1 and AGS2, respectively. Lung invasion in infected mice is significantly higher in the mutant than in the wild type. The mutant has a better resistance to reactive oxygen species and a quicker germination rate	Aspergillus fumigatus

Organism

Organism	UniProt	Comment	Textmining
Aspergillus fumigatus	-	G10 a spontaneous nitrate reductase mutant of strain CBS 144-89	-

Synonyms

Synonyms	Comment	Organism
AGS3	-	Aspergillus fumigatus
AGS3	a gene coding for a putative alpha(1-3)glucan synthase	Aspergillus fumigatus

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Release 2023.1 (January 2023)