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Literature summary for 2.4.1.183 extracted from

  • Yamashita, Y.; Hanada, N.; Itoh-Andoh, M.; Takehara, T.
    Evidence for the presence of two distinct sites of sucrose hydrolysis and glucosyl transfer activities on 1,3-alpha-D-glucan synthase of Streptococcus mutans (1989), FEBS Lett., 243, 343-346.
    View publication on PubMed
Search for more literature for 2.4.1.183

Inhibitors

Inhibitors Comment Organism Structure
Antiserum against the isolated 1,3-alpha-D-glucan synthase glucosyl transfer activity is completely inhibited, not sucrose hydrolysis activity Streptococcus mutans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucose + [alpha-D-glucosyl-(1-3)]n Streptococcus mutans
-
 UDP + [alpha-D-glucosyl-(1-3)]n+1
-
 ?
UDP-glucose + [alpha-D-glucosyl-(1-3)]n Streptococcus mutans AHT
-
 UDP + [alpha-D-glucosyl-(1-3)]n+1
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus mutans
-
 AHT strain
-
Streptococcus mutans AHT
-
 AHT strain
-

Purification (Commentary)

Purification (Comment) Organism
-
 Streptococcus mutans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + [alpha-D-glucosyl-(1-3)]n
-
 Streptococcus mutans UDP + [alpha-D-glucosyl-(1-3)]n+1
-
 ?
UDP-glucose + [alpha-D-glucosyl-(1-3)]n enzyme catalyzes both the hydrolysis of sucrose to glucose and fructose and the glucosyl transfer to glucosyl polymers to yield water-insoluble glucan involving 2 different active sites, the enzyme catalyzes only sucrose hydrolysis however in the absence of 1,6-alpha-D-glucan as acceptor Streptococcus mutans UDP + [alpha-D-glucosyl-(1-3)]n+1
-
 ?
UDP-glucose + [alpha-D-glucosyl-(1-3)]n a glucan primer is needed to begin the reaction which brings about elongation of the glucan chains Streptococcus mutans UDP + [alpha-D-glucosyl-(1-3)]n+1
-
 ?
UDP-glucose + [alpha-D-glucosyl-(1-3)]n introduction of an alpha-1,3-linkage branch at the C3-position to the alpha-1,6-chain Streptococcus mutans UDP + [alpha-D-glucosyl-(1-3)]n+1
-
 ?
UDP-glucose + [alpha-D-glucosyl-(1-3)]n
-
 Streptococcus mutans AHT UDP + [alpha-D-glucosyl-(1-3)]n+1
-
 ?
UDP-glucose + [alpha-D-glucosyl-(1-3)]n enzyme catalyzes both the hydrolysis of sucrose to glucose and fructose and the glucosyl transfer to glucosyl polymers to yield water-insoluble glucan involving 2 different active sites, the enzyme catalyzes only sucrose hydrolysis however in the absence of 1,6-alpha-D-glucan as acceptor Streptococcus mutans AHT UDP + [alpha-D-glucosyl-(1-3)]n+1
-
 ?
UDP-glucose + [alpha-D-glucosyl-(1-3)]n a glucan primer is needed to begin the reaction which brings about elongation of the glucan chains Streptococcus mutans AHT UDP + [alpha-D-glucosyl-(1-3)]n+1
-
 ?
UDP-glucose + [alpha-D-glucosyl-(1-3)]n introduction of an alpha-1,3-linkage branch at the C3-position to the alpha-1,6-chain Streptococcus mutans AHT UDP + [alpha-D-glucosyl-(1-3)]n+1
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 assay at Streptococcus mutans