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Literature summary for 2.4.1.175 extracted from

  • Izumikawa, T.; Uyama, T.; Okuura, Y.; Sugahara, K.; Kitagawa, H.
    Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor (2007), Biochem. J., 403, 545-552.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.175

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HeLa cells Homo sapiens
soluble form of the enzyme lacking the first 129 amino acids expressed as protein A fusion protein in COS-1 cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens possess N-acetylgalactosaminyltransferase-II and glucuronyltransferase-II activities responsible for the elongation of chondroitin sulfate chains but cannot polymerize chondroitin chains by themselves ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens A2V663
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
colon
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
leukocyte from peripheral blood Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-
small intestine
-
 Homo sapiens
-
spleen
-
 Homo sapiens
-
thymus
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-thrombomodulin + UDP-N-acetyl-D-galactosamine + UDP-glucuronic acid
-
 Homo sapiens ?
-
 ?
additional information possess N-acetylgalactosaminyltransferase-II and glucuronyltransferase-II activities responsible for the elongation of chondroitin sulfate chains but cannot polymerize chondroitin chains by themselves Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
chondroitin sulfate synthase-3
-
 Homo sapiens
chondroitin synthase-2 based on the experimental results chondroitin sulfate synthase-3 is renamed into chondroitin synthase-2 Homo sapiens
ChSy-2
-
 Homo sapiens
CSS3
-
 Homo sapiens