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Literature summary for 2.4.1.174 extracted from

  • Zheng, J.; Wu, C.; Ma, W.; Zhang, Y.; Hou, T.; Xu, H.; Wu, S.; Yao, X.; Guo, X.
    Abnormal expression of chondroitin sulphate N-acetylgalactosaminyltransferase 1 and Hapln-1 in cartilage with Kashin-Beck disease and primary osteoarthritis (2013), Int. Orthop., 37, 2051-2059.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene CSGALNACT1, quantitative real-time PCR enzyme expression analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TDX6 gene csgalnact1
-

Source Tissue

Source Tissue Comment Organism Textmining
cartilage articular Homo sapiens
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chondrocyte
-
 Homo sapiens
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additional information immunohistochemic analysis of enzyme content and localization, overview Homo sapiens
-

Synonyms

Synonyms Comment Organism
chondroitin sulphate N-acetylgalactosaminyltransferase 1
-
 Homo sapiens
CSGalNAcT-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is downregulated in Kashin-Beck disease (KBD), an endemic degenerative osteoarthritis, and in primary osteoarthritis, both associated with extracellular matrix degradation down

General Information

General Information Comment Organism
malfunction the enzyme is downregulated in Kashin-Beck disease (KBD), an endemic degenerative osteoarthritis, and in primary osteoarthritis, both associated with extracellular matrix degradation. Enzyme CSGalNAcT-1 may be involved in the damage of articular cartilage of Kashin-Beck disease and osteoarthritis by regulating Hapln-1 in the Wnt/beta-catenin signalling pathway. Alterations of involved enzyme expressions in CSGalNAcT gene network in case of Kashin-Beck disease and osteoarthritis Homo sapiens
physiological function chondroitin sulfate N-acetylgalactosaminyl-transferase-1 is an essential enzyme in chondroitin sulfate metabolism and participates in chondroitin sulfate chain formation of aggrecan, and plays an important role in degenerative extracellular matrix of cartilage Homo sapiens