Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-naphthol | - |
Homo sapiens | |
chrysin | - |
Homo sapiens | |
efavirenz | - |
Homo sapiens | |
lithocholic acid | - |
Homo sapiens | |
sauchinone | noncompetitive inhibition; noncompetitive inhibition | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P16662 | - |
- |
Homo sapiens | P19224 | - |
- |
Homo sapiens | P22309 | - |
- |
Homo sapiens | P35503 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-estradiol + UDP-glucuronate | substrate for isoform UGT1A1 | Homo sapiens | UDP + beta-estradiol-3-glucuronide | - |
? | |
chenodeoxycholic acid + UDP-glucuronate | substrate for isoform UGT1A3 | Homo sapiens | UDP + ? | - |
? | |
serotonin + UDP-glucuronate | substrate for isoform UGT1A6 | Homo sapiens | UDP + serotonin beta-D-glucuronide | - |
? | |
zidovudine + UDP-glucuronate | substrate for isoform UGT2B7 | Homo sapiens | UDP + zidovudine beta-D-glucuronide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UGT1A1 | isoform | Homo sapiens |
UGT1A3 | isoform | Homo sapiens |
UGT1A6 | isoform | Homo sapiens |
UGT2B7 | isoform | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000524 | - |
sauchinone | isoform UGT2B7, at pH 7.6 and 37°C | Homo sapiens | |
0.00108 | - |
sauchinone | isoform UGT1A6, at pH 7.6 and 37°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000279 | - |
isoform UGT2B7, at pH 7.6 and 37°C | Homo sapiens | sauchinone | |
0.000758 | - |
isoform UGT1A6, at pH 7.6 and 37°C | Homo sapiens | sauchinone | |
0.00883 | - |
isoform UGT1A1, at pH 7.6 and 37°C | Homo sapiens | sauchinone | |
0.0283 | - |
isoform UGT1A1, at pH 7.6 and 37°C | Homo sapiens | chrysin | |
0.0352 | - |
isoform UGT1A6, at pH 7.6 and 37°C | Homo sapiens | 1-naphthol | |
0.0439 | - |
isoform UGT1A3, at pH 7.6 and 37°C | Homo sapiens | sauchinone | |
0.0698 | - |
isoform UGT1A3, at pH 7.6 and 37°C | Homo sapiens | lithocholic acid | |
0.0754 | - |
isoform UGT2B7, at pH 7.6 and 37°C | Homo sapiens | efavirenz |