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Literature summary for 2.4.1.17 extracted from

  • Kim, K.; Zheng, F.; Zhan, C.G.
    Oligomerization and catalytic parameters of human UDP-glucuronosyltransferase 1A10 expression and characterization of the recombinant protein (2018), Drug Metab. Dispos., 46, 1446-1452 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 and CHO cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0457
-
entacapone membrane-bound recombinant isoform UGT1A10 from CHO cells, at pH 7.4 and 37°C Homo sapiens
0.0569
-
entacapone membrane-bound recombinant isoform UGT1A10 from HEK-293 cells, at pH 7.4 and 37°C Homo sapiens
0.554
-
entacapone with phospholipid purified recombinant isoform UGT1A10 from CHO cells, at pH 7.4 and 37°C Homo sapiens
0.703
-
entacapone without phospholipid purified recombinant isoform UGT1A10 from CHO cells, at pH 7.4 and 37°C Homo sapiens
7.3
-
morphine membrane-bound recombinant isoform UGT1A10 from CHO cells, at pH 7.4 and 37°C Homo sapiens
10.4
-
morphine membrane-bound recombinant isoform UGT1A10 from HEK-293 cells, at pH 7.4 and 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 5 mM used in assay conditions Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
HisPur cobalt resin column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
gastrointestinal tract
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
entacapone + UDP-glucuronate
-
Homo sapiens UDP + entacapone-3-O-glucuronide
-
?
morphine + UDP-glucuronate
-
Homo sapiens UDP + morphine-3-glucuronide
-
?

Subunits

Subunits Comment Organism
? x * 65000, His6-tagged recombinant enzyme, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase
-
Homo sapiens
UGT1A10 isoform Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0013
-
entacapone without phospholipid purified recombinant isoform UGT1A10 from CHO cells, at pH 7.4 and 37°C Homo sapiens
0.0027
-
entacapone with phospholipid purified recombinant isoform UGT1A10 from CHO cells, at pH 7.4 and 37°C Homo sapiens
0.015
-
morphine membrane-bound recombinant isoform UGT1A10 from HEK-293 cells, at pH 7.4 and 37°C Homo sapiens
0.073
-
entacapone membrane-bound recombinant isoform UGT1A10 from HEK-293 cells, at pH 7.4 and 37°C Homo sapiens
0.138
-
morphine membrane-bound recombinant isoform UGT1A10 from CHO cells, at pH 7.4 and 37°C Homo sapiens
0.422
-
entacapone membrane-bound recombinant isoform UGT1A10 from CHO cells, at pH 7.4 and 37°C Homo sapiens

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.00144
-
morphine membrane-bound recombinant isoform UGT1A10 from HEK-293 cells, at pH 7.4 and 37°C Homo sapiens
0.00187
-
entacapone without phospholipid purified recombinant isoform UGT1A10 from CHO cells, at pH 7.4 and 37°C Homo sapiens
0.0048
-
entacapone with phospholipid purified recombinant isoform UGT1A10 from CHO cells, at pH 7.4 and 37°C Homo sapiens
0.0188
-
morphine membrane-bound recombinant isoform UGT1A10 from CHO cells, at pH 7.4 and 37°C Homo sapiens
1.285
-
entacapone membrane-bound recombinant isoform UGT1A10 from HEK-293 cells, at pH 7.4 and 37°C Homo sapiens
9.22
-
entacapone membrane-bound recombinant isoform UGT1A10 from CHO cells, at pH 7.4 and 37°C Homo sapiens