Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-OH-PCB106 | 2'-hydroxy metabolite of polychlorinated biphenyl 106, competitive inhibition | Homo sapiens | |
4'-OH-PCB106 | 4'-hydroxy metabolite of polychlorinated biphenyl 106, competitive inhibition | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | 5 mM used in assay conditions | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferone + UDP-glucuronate | - |
Homo sapiens | UDP + 4-methylumbelliferyl beta-D-glucuronide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UGT1A1 | isoform | Homo sapiens |
UGT1A7 | isoform | Homo sapiens |
UGT2B7 | isoform | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0004 | - |
2'-OH-PCB106 | isoform UGT1A1, at pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.0007 | - |
4'-OH-PCB106 | isoform UGT1A1, at pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.0013 | - |
2'-OH-PCB106 | isoform UGT1A7, at pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.0027 | - |
2'-OH-PCB106 | isoform UGT2B7, at pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.0048 | - |
4'-OH-PCB106 | isoform UGT2B7, at pH 7.4, temperature not specified in the publication | Homo sapiens | |
0.0068 | - |
4'-OH-PCB106 | isoform UGT1A7, at pH 7.4, temperature not specified in the publication | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00156 | - |
isoform UGT1A1, at pH 7.4, temperature not specified in the publication | Homo sapiens | 4'-OH-PCB106 | |
0.0016 | - |
isoform UGT1A1, at pH 7.4, temperature not specified in the publication | Homo sapiens | 2'-OH-PCB106 | |
0.00276 | - |
isoform UGT2B7, at pH 7.4, temperature not specified in the publication | Homo sapiens | 2'-OH-PCB106 | |
0.00551 | - |
isoform UGT2B7, at pH 7.4, temperature not specified in the publication | Homo sapiens | 4'-OH-PCB106 | |
0.01502 | - |
isoform UGT1A7, at pH 7.4, temperature not specified in the publication | Homo sapiens | 2'-OH-PCB106 | |
0.03047 | - |
isoform UGT1A7, at pH 7.4, temperature not specified in the publication | Homo sapiens | 4'-OH-PCB106 |