Literature summary for 2.4.1.17 extracted from

Du, Z.; Cao, Y.F.; Li, S.N.; Hu, C.M.; Fu, Z.W.; Huang, C.T.; Sun, X.Y.; Liu, Y.Z.; Yang, K.; Fang, Z.Z.
Inhibition of UDP-glucuronosyltransferases (UGTs) by phthalate monoesters (2018), Chemosphere, 197, 7-13 .

Search for more literature for 2.4.1.17

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in baculovirus-infected insect cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
monobenzyl phthalate	isoform UGT1A9 shows 92.49% inhibition at 0.1 mM	Homo sapiens
monobutyl phthalate	-	Homo sapiens
monocyclohexyl phthalate	isoform UGT1A9 shows 95.9% inhibition at 0.1 mM	Homo sapiens
monoethyl phthalate	-	Homo sapiens
monoethylhexyl phthalate	isoform UGT1A7 shows 85.26% inhibition at 0.1 mM, isoform UGT1A9 shows 97.61% inhibition at 0.1 mM	Homo sapiens
monohexyl phthalate	isoform UGT1A9 shows 85.83% inhibition at 0.1 mM	Homo sapiens
monomethyl phthalate	-	Homo sapiens
monooctyl phthalate	isoform UGT1A9 shows 91.21% inhibition at 0.1 mM	Homo sapiens
additional information	0.1 mM phthalate monoesters exhibit weak inhibition towards isoforms UGT1A10, UGT2B4, UGT2B7, UGT2B15 and UGT2B17 by reducing the glucuronidation less than 80%	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	5 mM used in assay conditions	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-methylumbelliferone + UDP-glucuronate	-	Homo sapiens	UDP + 4-methylumbelliferyl beta-D-glucuronide	-	?

Synonyms

Synonyms	Comment	Organism
UDP-glucuronosyltransferase	-	Homo sapiens
UGT1A1	isoform	Homo sapiens
UGT1A10	isoform	Homo sapiens
UGT1A3	isoform	Homo sapiens
UGT1A6	isoform	Homo sapiens
UGT1A7	isoform	Homo sapiens
UGT1A8	isoform	Homo sapiens
UGT1A9	isoform	Homo sapiens
UGT2B15	isoform	Homo sapiens
UGT2B17	isoform	Homo sapiens
UGT2B4	isoform	Homo sapiens
UGT2B7	isoform	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00009	-	monocyclohexyl phthalate	isoform UGT1A9, at pH 7.4 and 37°C	Homo sapiens
0.00016	-	monooctyl phthalate	isoform UGT1A9, at pH 7.4 and 37°C	Homo sapiens
0.00117	-	monoethylhexyl phthalate	isoform UGT1A9, at pH 7.4 and 37°C	Homo sapiens
0.00213	-	monobenzyl phthalate	isoform UGT1A9, at pH 7.4 and 37°C	Homo sapiens
0.00746	-	monohexyl phthalate	isoform UGT1A9, at pH 7.4 and 37°C	Homo sapiens
0.01125	-	monoethylhexyl phthalate	isoform UGT1A7, at pH 7.4 and 37°C	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00157	-	isoform UGT1A9, at pH 7.4 and 37°C	Homo sapiens	monoethylhexyl phthalate
0.00329	-	isoform UGT1A9, at pH 7.4 and 37°C	Homo sapiens	monocyclohexyl phthalate
0.00758	-	isoform UGT1A9, at pH 7.4 and 37°C	Homo sapiens	monooctyl phthalate
0.00936	-	isoform UGT1A9, at pH 7.4 and 37°C	Homo sapiens	monobenzyl phthalate
0.01071	-	isoform UGT1A7, at pH 7.4 and 37°C	Homo sapiens	monoethylhexyl phthalate
0.01246	-	isoform UGT1A9, at pH 7.4 and 37°C	Homo sapiens	monohexyl phthalate

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Release 2023.1 (January 2023)