Cloned (Comment) | Organism |
---|---|
expressed in Saccharomyces cerevisiae strain AH22 | Macaca fascicularis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0095 | - |
estradiol | isoform UGT2B30, at pH 7.4, temperature not specified in the publication | Macaca fascicularis | |
0.013 | - |
estradiol | isoform UGT2B9, at pH 7.4, temperature not specified in the publication | Macaca fascicularis | |
1.2 | - |
morphine | isoform UGT2B30, at pH 7.4, temperature not specified in the publication | Macaca fascicularis | |
1.3 | - |
morphine | isoform UGT2B9, at pH 7.4, temperature not specified in the publication | Macaca fascicularis | |
2.3 | - |
estradiol | enzyme from liver microsome, at pH 7.4, temperature not specified in the publication | Macaca fascicularis | |
2.7 | - |
morphine | enzyme from liver microsome, at pH 7.4, temperature not specified in the publication | Macaca fascicularis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-alpha-D-glucuronate + acceptor | Macaca fascicularis | - |
UDP + acceptor beta-D-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Macaca fascicularis | - |
- |
- |
Macaca fascicularis | A0A4Y1K7J9 | isoform UGT2A2 | - |
Macaca fascicularis | A0A4Y1KAF7 | isoform UGT2A1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
jejunum | predominant expression of isoform UGT2B9 | Macaca fascicularis | - |
kidney | predominant expression of isoforms UGT2A3 and UGT2B18 | Macaca fascicularis | - |
liver | predominant expression of isoforms UGT2B19, UGT2B23, UGT2B33, UGT2B30, UGT2B20 | Macaca fascicularis | - |
nasal mucosa | predominant expression of isoform UGT2A1 | Macaca fascicularis | - |
nasal mucosa | predominant expression of isoform UGT2A2 | Macaca fascicularis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferone + UDP-glucuronate | the reaction occurs with isoform UGT2B20 | Macaca fascicularis | UDP + 4-methylumbelliferyl beta-D-glucuronide | - |
? | |
4-nitrophenol + UDP-glucuronate | the reaction occurs with isoform UGT2B30 | Macaca fascicularis | UDP + 4-nitrophenyl beta-D-glucuronide | - |
? | |
estradiol + UDP-glucuronate | the reaction occurs with isoforms UGT2B9 and UGT2B30 | Macaca fascicularis | UDP + estradiol 17-O-glucuronide | - |
? | |
imipramine + UDP-glucuronate | the reaction occurs with isoform UGT2B20 | Macaca fascicularis | UDP + imipramine D-glucuronide | - |
? | |
additional information | isoforms UGT2B9 and UGT2B30 do not show activities in estradiol 3-O-glucuronidation | Macaca fascicularis | ? | - |
- |
|
morphine + UDP-glucuronate | the reaction occurs with isoforms UGT2B9 and UGT2B30 | Macaca fascicularis | UDP + morphine 3-O-glucuronide | - |
? | |
UDP-alpha-D-glucuronate + acceptor | - |
Macaca fascicularis | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-alpha-D-glucuronate + estradiol | - |
Macaca fascicularis | UDP + estradiol beta-D-glucuronoside | - |
? | |
UDP-alpha-D-glucuronate + morphine | - |
Macaca fascicularis | UDP + morphine beta-D-glucuronoside | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase 2 | - |
Macaca fascicularis |
UGT2A1 | isoform | Macaca fascicularis |
UGT2A2 | isoform | Macaca fascicularis |
UGT2A3 | isoform | Macaca fascicularis |
UGT2B18 | isoform | Macaca fascicularis |
UGT2B19 | isoform | Macaca fascicularis |
UGT2B20 | isoform | Macaca fascicularis |
UGT2B23 | isoform | Macaca fascicularis |
UGT2B30 | isoform | Macaca fascicularis |
UGT2B33 | isoform | Macaca fascicularis |
UGT2B9 | isoform | Macaca fascicularis |