Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.17 extracted from

  • Uno, Y.; Takahira, R.; Murayama, N.; Onozeki, S.; Kawamura, S.; Uehara, S.; Ikenaka, Y.; Ishizuka, M.; Ikushiro, S.; Yamazaki, H.
    Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques (2019), Biochem. Pharmacol., 163, 335-344 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae strain AH22 Macaca fascicularis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0095
-
estradiol isoform UGT2B30, at pH 7.4, temperature not specified in the publication Macaca fascicularis
0.013
-
estradiol isoform UGT2B9, at pH 7.4, temperature not specified in the publication Macaca fascicularis
1.2
-
morphine isoform UGT2B30, at pH 7.4, temperature not specified in the publication Macaca fascicularis
1.3
-
morphine isoform UGT2B9, at pH 7.4, temperature not specified in the publication Macaca fascicularis
2.3
-
estradiol enzyme from liver microsome, at pH 7.4, temperature not specified in the publication Macaca fascicularis
2.7
-
morphine enzyme from liver microsome, at pH 7.4, temperature not specified in the publication Macaca fascicularis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-glucuronate + acceptor Macaca fascicularis
-
UDP + acceptor beta-D-glucuronoside
-
?

Organism

Organism UniProt Comment Textmining
Macaca fascicularis
-
-
-
Macaca fascicularis A0A4Y1K7J9 isoform UGT2A2
-
Macaca fascicularis A0A4Y1KAF7 isoform UGT2A1
-

Source Tissue

Source Tissue Comment Organism Textmining
jejunum predominant expression of isoform UGT2B9 Macaca fascicularis
-
kidney predominant expression of isoforms UGT2A3 and UGT2B18 Macaca fascicularis
-
liver predominant expression of isoforms UGT2B19, UGT2B23, UGT2B33, UGT2B30, UGT2B20 Macaca fascicularis
-
nasal mucosa predominant expression of isoform UGT2A1 Macaca fascicularis
-
nasal mucosa predominant expression of isoform UGT2A2 Macaca fascicularis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-methylumbelliferone + UDP-glucuronate the reaction occurs with isoform UGT2B20 Macaca fascicularis UDP + 4-methylumbelliferyl beta-D-glucuronide
-
?
4-nitrophenol + UDP-glucuronate the reaction occurs with isoform UGT2B30 Macaca fascicularis UDP + 4-nitrophenyl beta-D-glucuronide
-
?
estradiol + UDP-glucuronate the reaction occurs with isoforms UGT2B9 and UGT2B30 Macaca fascicularis UDP + estradiol 17-O-glucuronide
-
?
imipramine + UDP-glucuronate the reaction occurs with isoform UGT2B20 Macaca fascicularis UDP + imipramine D-glucuronide
-
?
additional information isoforms UGT2B9 and UGT2B30 do not show activities in estradiol 3-O-glucuronidation Macaca fascicularis ?
-
-
morphine + UDP-glucuronate the reaction occurs with isoforms UGT2B9 and UGT2B30 Macaca fascicularis UDP + morphine 3-O-glucuronide
-
?
UDP-alpha-D-glucuronate + acceptor
-
Macaca fascicularis UDP + acceptor beta-D-glucuronoside
-
?
UDP-alpha-D-glucuronate + estradiol
-
Macaca fascicularis UDP + estradiol beta-D-glucuronoside
-
?
UDP-alpha-D-glucuronate + morphine
-
Macaca fascicularis UDP + morphine beta-D-glucuronoside
-
?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase 2
-
Macaca fascicularis
UGT2A1 isoform Macaca fascicularis
UGT2A2 isoform Macaca fascicularis
UGT2A3 isoform Macaca fascicularis
UGT2B18 isoform Macaca fascicularis
UGT2B19 isoform Macaca fascicularis
UGT2B20 isoform Macaca fascicularis
UGT2B23 isoform Macaca fascicularis
UGT2B30 isoform Macaca fascicularis
UGT2B33 isoform Macaca fascicularis
UGT2B9 isoform Macaca fascicularis