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Literature summary for 2.4.1.17 extracted from

  • Higashi, E.; Ando, A.; Iwano, S.; Murayama, N.; Yamazaki, H.; Miyamoto, Y.
    Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig (2014), Biopharm. Drug Dispos., 35, 313-320.
    View publication on PubMed
Search for more literature for 2.4.1.17

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-
microsome
-
 Rattus norvegicus
-
-
microsome
-
 Sus scrofa
-
-
microsome
-
 Canis lupus familiaris
-
-
microsome
-
 Macaca fascicularis
-
-
microsome
-
 Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus
Mg2+ required Rattus norvegicus
Mg2+ required Sus scrofa
Mg2+ required Canis lupus familiaris
Mg2+ required Macaca fascicularis
Mg2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
 beagle dogs
-
Homo sapiens O60656 gene UGT1A9
-
Homo sapiens P16662 gene UGT2B7
-
Homo sapiens P19224 gene UGT1A6
-
Homo sapiens P22309 gene UGT1A1
-
Homo sapiens P22310 gene UGT1A4
-
Macaca fascicularis
-
 cynomolgus monkeys
-
Mus musculus
-
 ICR mice
-
Rattus norvegicus
-
 SD rats
-
Sus scrofa
-
 Yucatan minipig
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-
liver
-
 Rattus norvegicus
-
liver
-
 Canis lupus familiaris
-
liver
-
 Macaca fascicularis
-
liver
-
 Homo sapiens
-
liver UGT activities in the microminipig are similar to those in the minipig Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Mus musculus
additional information
-
 hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Rattus norvegicus
additional information
-
 hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Canis lupus familiaris
additional information
-
 hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Macaca fascicularis
additional information
-
 hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes Sus scrofa
additional information
-
 hepatic UGTactivity with selective substrates of human in the microminipig compared to those in humans and other experimental animals, overview. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and the other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview. 3'-Azido-3'-deoxythymidine glucuronidation is approximately 26fold lower in microminipig microsomes than in human microsomes Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information 3'-azido-3'-deoxythymidine-glucuronidation activity is low in the microminipig compared with humans, morphine-3-glucuronidation activity in the microminipig is higher than that in humans Sus scrofa ?
-
 ?
additional information 3'-azido-3'-deoxythymidine-glucuronidation activity is low in the microminipig compared with humans, morphine-3-glucuronidation activity in the microminipig is higher than that in humans Homo sapiens ?
-
 ?
additional information no activity with imipramine Canis lupus familiaris ?
-
 ?
UDP-glucuronate + 17-beta-estradiol
-
 Mus musculus UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-beta-estradiol
-
 Rattus norvegicus UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-beta-estradiol
-
 Canis lupus familiaris UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-beta-estradiol
-
 Macaca fascicularis UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-beta-estradiol
-
 Homo sapiens UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-beta-estradiol high levels of estradiol-3-glucuronidation in microsomes of 1-day-old microminipigs Sus scrofa UDP + 17-beta-estradiol 3-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
-
 Mus musculus UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
 ?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
-
 Rattus norvegicus UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
 ?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
-
 Sus scrofa UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
 ?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
-
 Canis lupus familiaris UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
 ?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
-
 Macaca fascicularis UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
 ?
UDP-glucuronate + 3'-azido-3'-deoxythymidine
-
 Homo sapiens UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronoside
-
 ?
UDP-glucuronate + imipramine
-
 Sus scrofa UDP + imipramine N-beta-D-glucuronoside
-
 ?
UDP-glucuronate + imipramine specific substrate of UGT1A4 Homo sapiens UDP + imipramine N-beta-D-glucuronoside
-
 ?
UDP-glucuronate + morphine
-
 Mus musculus UDP + morphine 3-beta-D-glucuronoside
-
 ?
UDP-glucuronate + morphine
-
 Rattus norvegicus UDP + morphine 3-beta-D-glucuronoside
-
 ?
UDP-glucuronate + morphine
-
 Sus scrofa UDP + morphine 3-beta-D-glucuronoside
-
 ?
UDP-glucuronate + morphine
-
 Canis lupus familiaris UDP + morphine 3-beta-D-glucuronoside
-
 ?
UDP-glucuronate + morphine
-
 Macaca fascicularis UDP + morphine 3-beta-D-glucuronoside
-
 ?
UDP-glucuronate + morphine
-
 Homo sapiens UDP + morphine 3-beta-D-glucuronoside
-
 ?
UDP-glucuronate + morphine morphine-3-glucuronidation is a marker of conjugation by human UGT2B7 Homo sapiens UDP + morphine 3-beta-D-glucuronoside
-
 ?
UDP-glucuronate + propofol
-
 Mus musculus UDP + propofol beta-D-glucuronoside
-
 ?
UDP-glucuronate + propofol
-
 Rattus norvegicus UDP + propofol beta-D-glucuronoside
-
 ?
UDP-glucuronate + propofol
-
 Sus scrofa UDP + propofol beta-D-glucuronoside
-
 ?
UDP-glucuronate + propofol
-
 Canis lupus familiaris UDP + propofol beta-D-glucuronoside
-
 ?
UDP-glucuronate + propofol
-
 Macaca fascicularis UDP + propofol beta-D-glucuronoside
-
 ?
UDP-glucuronate + propofol
-
 Homo sapiens UDP + propofol beta-D-glucuronoside
-
 ?
UDP-glucuronate + serotonin
-
 Mus musculus UDP + serotonin beta-D-glucuronoside
-
 ?
UDP-glucuronate + serotonin
-
 Rattus norvegicus UDP + serotonin beta-D-glucuronoside
-
 ?
UDP-glucuronate + serotonin
-
 Sus scrofa UDP + serotonin beta-D-glucuronoside
-
 ?
UDP-glucuronate + serotonin
-
 Canis lupus familiaris UDP + serotonin beta-D-glucuronoside
-
 ?
UDP-glucuronate + serotonin
-
 Macaca fascicularis UDP + serotonin beta-D-glucuronoside
-
 ?
UDP-glucuronate + serotonin
-
 Homo sapiens UDP + serotonin beta-D-glucuronoside
-
 ?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase
-
 Mus musculus
UDP-glucuronosyltransferase
-
 Rattus norvegicus
UDP-glucuronosyltransferase
-
 Sus scrofa
UDP-glucuronosyltransferase
-
 Canis lupus familiaris
UDP-glucuronosyltransferase
-
 Macaca fascicularis
UDP-glucuronosyltransferase
-
 Homo sapiens
UGT
-
 Mus musculus
UGT
-
 Rattus norvegicus
UGT
-
 Sus scrofa
UGT
-
 Canis lupus familiaris
UGT
-
 Macaca fascicularis
UGT
-
 Homo sapiens
UGT1A1
-
 Homo sapiens
UGT1A4
-
 Homo sapiens
UGT1A6
-
 Homo sapiens
UGT1A9
-
 Homo sapiens
UGT2B7
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus
37
-
 assay at Rattus norvegicus
37
-
 assay at Sus scrofa
37
-
 assay at Canis lupus familiaris
37
-
 assay at Macaca fascicularis
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus
7.4
-
 assay at Rattus norvegicus
7.4
-
 assay at Sus scrofa
7.4
-
 assay at Canis lupus familiaris
7.4
-
 assay at Macaca fascicularis
7.4
-
 assay at Homo sapiens

General Information

General Information Comment Organism
evolution UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Mus musculus
evolution UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Rattus norvegicus
evolution UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Sus scrofa
evolution UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Canis lupus familiaris
evolution UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Macaca fascicularis
evolution UGTs have been divided into two families: UGT1 and UGT2, based on similarities between their amino acid sequences and gene organization. Hepatic UGTactivity in the microminipig compared to those in humans and other experimental animals. Estradiol-3-glucuronidation activity is higher in the microminipig than in humans and other animals, serotonin glucuronide formation activity is 20-55fold higher in mouse and rat liver microsomes than in microsomes from the other animals. Glucuronidation activities are 2fold higher in microminipig microsomes than in human, dog or monkey microsomes, overview Homo sapiens
physiological function glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds Mus musculus
physiological function glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds Rattus norvegicus
physiological function glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds Sus scrofa
physiological function glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds Canis lupus familiaris
physiological function glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds Macaca fascicularis
physiological function glucuronidation catalysed by UDP-glucuronosyltransferase is an important pathway in the metabolism of xenobiotics and endogenous compounds Homo sapiens