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Literature summary for 2.4.1.17 extracted from

  • He, Y.Q.; Liu, Y.; Zhang, B.F.; Liu, H.X.; Lu, Y.L.; Yang, L.; Xiong, A.Z.; Xu, L.L.; Wang, C.H.; Yang, L.; Wang, Z.T.
    Identification of the UDP-glucuronosyltransferase isozyme involved in senecionine glucuronidation in human liver microsomes (2010), Drug Metab. Dispos., 38, 626-634.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
hecogenin noncompetitive inhibition of senecionine glucuronidation, more than 80% inhibition at 0.2 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.51
-
senecionine pH 7.4, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
senecionine + UDP-alpha-D-glucuronate senecionine is a representative of the hepatotoxic pyrrolizidine alkaloids. Glucuronidation is mediated by isofrom UGT1A4 and follows typical Michaelis-Menten kinetics Homo sapiens senecionine N-glucuronide + UDP
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0039
-
hecogenin pH 7.4, 37°C, substrate senecionine Homo sapiens