KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.034 | - |
S-naproxen | pH 7.4, 37°C, renal cortex microsomes | Homo sapiens | |
0.045 | - |
S-naproxen | pH 7.4, 37°C, renal medulla microsomes | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-alpha-D-glucuronate + (S)-naproxen | Homo sapiens | - |
UDP + beta-D-glucuronosyl (S)-naproxen | - |
? | |
UDP-D-glucuronate + acceptor | Homo sapiens | potential role of UGTs in regulating aldosterone | UDP + acceptor beta-D-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes UGT1A and UGT2B7 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | with the exception of the glomerulus, Bowmans capsule, and renal vasculature, isozymes UGT1A and UGT2B7 are expressed throughout the proximal and distal convoluted tubules, the loops of Henle, and the collecting ducts. Additionally, UGT1A and UGT2B7 expression occurs in the macula densa, immunolocalization of isozymes UGT1A and UGT2B7 in the renal cortex, overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-alpha-D-glucuronate + (S)-naproxen | - |
Homo sapiens | UDP + beta-D-glucuronosyl (S)-naproxen | - |
? | |
UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | potential role of UGTs in regulating aldosterone | Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UGT | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |