Cloned (Comment) | Organism |
---|---|
co-expression of His-tagged and HA-tagged isozymes UGT1A6 and UGT1A9 in baculovrisu-infected insect cells | Homo sapiens |
co-expression of isozyme UGT1A6 mutant Y485D with His-tagged isozyme UGT2B7 | Homo sapiens |
co-expression of isozyme UGT1A6 mutant Y485D with His-tagged isozyme UGT2B7, co-expression of isozyme UGT1A6 mutant Y485D with isozyme UGT1A4 showing high protein-protein interactions, co-expression of His-tagged and HA-tagged isozymes UGT1A6 and UGT1A9 in baculovirus-infected insect cells | Homo sapiens |
co-expression of isozyme UGT1A6 mutant Y485D with isozyme UGT1A4 showing high protein-protein interactions | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a truncated mutant of UGT1A6, whose transmembrane helix is deleted, is still associated to the endoplasmic reticulum membrane, overview | Homo sapiens |
additional information | a truncated mutant of UGT2B1, whose transmembrane helix is deleted, is still associated to the endoplasmic reticulum membrane, overview | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
beta-phenyllongifolol | specific for isozyme UGT2B7 | Homo sapiens | |
additional information | isozyme UGT1A6 is more sensitive to detergent inhibition as isozyme UGT1A9; isozyme UGT1A6 is more sensitive to detergent inhibition as isozyme UGT1A9 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | integral | Rattus norvegicus | 5789 | - |
endoplasmic reticulum membrane | integral | Homo sapiens | 5789 | - |
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | UGTs play an important role in the defense against potentially hazardous xenobiotics, and they participate in the metabolism and homeostasis of many endogenous compounds, including bilirubin and steroid hormones, overview | ? | - |
? | |
additional information | Homo sapiens | UGTs play an important role in the defense against potentially hazardous xenobiotics, and they participate in the metabolism and homeostasis of many endogenous compounds, including bilirubin and steroid hormones, overview | ? | - |
? | |
UDP-D-glucuronate + acceptor | Rattus norvegicus | - |
UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | Homo sapiens | - |
UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-glucuronate + acceptor | Homo sapiens | - |
UDP + acceptor beta-glucuronoside | - |
? | |
UDP-glucuronate + serotonin | Homo sapiens | isozyme UGT2B7 | UDP + serotonin beta-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60656 | isozyme UGT1A9; isozyme UGT1A9 | - |
Homo sapiens | P16662 | isozyme UGT2B7; isozyme UGT2B7 | - |
Homo sapiens | P19224 | isozyme UGT1A6; isozyme UGT1A6 | - |
Homo sapiens | P22310 | isozyme UGT1A4; isozyme UGT1A4 | - |
Rattus norvegicus | - |
several isozymes, UGT1A isozyme occur in Wistar rats, not in Gunn rats | - |
Purification (Comment) | Organism |
---|---|
recombinant His-tagged isozyme UGT1A9 by nickel affinity chromatography | Homo sapiens |
recombinant isozyme UGT1A6 mutant Y485D with isozyme UGT1A4, after co-expression, by affinity chromatography | Homo sapiens |
recombinant isozyme UGT1A6 mutant Y485D with isozyme UGT1A4, after co-expression, by affinity chromatography, recombinant His-tagged isozyme UGT1A6 by nickel affinity chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Rattus norvegicus | - |
intestine | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Homo sapiens | - |
additional information | wide tissue distribution | Rattus norvegicus | - |
additional information | wide tissue distribution | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | UGTs play an important role in the defense against potentially hazardous xenobiotics, and they participate in the metabolism and homeostasis of many endogenous compounds, including bilirubin and steroid hormones, overview | Rattus norvegicus | ? | - |
? | |
additional information | UGTs play an important role in the defense against potentially hazardous xenobiotics, and they participate in the metabolism and homeostasis of many endogenous compounds, including bilirubin and steroid hormones, overview | Homo sapiens | ? | - |
? | |
additional information | tight protein-protein interaction between members of subfamilies UGT1A and UGT2B | Rattus norvegicus | ? | - |
? | |
UDP-D-glucuronate + acceptor | - |
Rattus norvegicus | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | differences in substrate binding between isozymes of different oligomeric state, overview | Rattus norvegicus | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | differences in substrate binding between isozymes of different oligomeric state, overview | Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-glucuronoside | - |
? | |
UDP-glucuronate + acceptor | differences in substrate binding between isozymes of different oligomeric state, overview | Homo sapiens | UDP + acceptor beta-glucuronoside | - |
? | |
UDP-glucuronate + serotonin | isozyme UGT2B7 | Homo sapiens | UDP + serotonin beta-glucuronoside | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the enzyme is composed of an N-terminal domain with an aglycon binding site, a short transmembrane sequence, a C-terminal domain with UDP-glucuronic acid binding site, a transmembrane heleix and a cytoplasmic tail, primary to quarternary structure and oligomeric state analysis of several isozymes, homo- and heterooligomerization, detailed overview | Homo sapiens |
More | the enzyme is composed of an N-terminal domain with an aglycon binding site, a short transmembrane sequence, a C-terminal domain with UDP-glucuronic acid binding site, a transmembrane helix and a cytoplasmic tail, primary to quarternary structure and oligomeric state analysis of several isozymes, detailed overview | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
More | UGTs belong to the GT1 family of glycosyltransferases | Homo sapiens |
UDP-glucuronosyltransferase | - |
Rattus norvegicus |
UDP-glucuronosyltransferase | - |
Homo sapiens |
UGT | - |
Rattus norvegicus |
UGT | - |
Homo sapiens |
UGT1A4 | - |
Homo sapiens |
UGT1A6 | - |
Homo sapiens |
UGT1A9 | - |
Homo sapiens |
UGT2B7 | - |
Homo sapiens |