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Literature summary for 2.4.1.17 extracted from

  • Kurkela, M.; Patana, A.S.; Mackenzie, P.I.; Court, M.H.; Tate, C.G.; Hirvonen, J.; Goldman, A.; Finel, M.
    Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6 (2007), Pharmacogenet. Genomics, 17, 115-126.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
UGT1A1 that contains the Y486D mutation (1A1 numbering) is expressed as His-tagged protein in thebaculovirus-infected insect cells Homo sapiens
UGT1A6 that contains the Y485D is expressed as His-tagged protein in thebaculovirus-infected insect cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
Y485D mutation lowers the normalized glucuronidation rate to 6% when the aglycone substrate is 1-naphthol. Km of the mutant enzyme for UDP-glucuronic acid is about 50 times higher than in UGT1A6. Coexpression of UGT1A6(Y485D) with UGT1A4 lowers the Km for UDP-glucuronic acid to the level of UGT1A6 Homo sapiens
Y486D mutation lowers the normalized glucuronidation rate to 13% when the aglycone substrate is 1-naphthol Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P19224
-
-
Homo sapiens P22309
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-naphthol + UDP-glucuronate
-
 Homo sapiens UDP + naphth-1-yl-beta-D-glucuronide
-
 ?
serotonin + UDP-glucuronate coexpression of UGT1A6 with UGT2B7 influences wild-type UGT1A6, increasing the normalized activity of UGT1A6 Homo sapiens UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide
-
 ?

Subunits

Subunits Comment Organism
More hetero-oligomerization may play an important role in UDP-glucuronosyltransferases activity Homo sapiens

Synonyms

Synonyms Comment Organism
UGT1A1
-
 Homo sapiens
UGT1A6
-
 Homo sapiens