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Literature summary for 2.4.1.17 extracted from

  • Chen, S.; Beaton, D.; Nguyen, N.; Senekeo-Effenberger, K.; Brace-Sinnokrak, E.; Argikar, U.; Remmel, R.P.; Trottier, J.; Barbier, O.; Ritter, J.K.; Tukey, R.H.
    Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus (2005), J. Biol. Chem., 280, 37547-37557.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of theUGT 1 locus in transgenic mice provides only a unique opportunity to examine the regulatory properties that control the tissue-specific and xenobiotic receptor-elicited expression patterns of the individual UGT1A genes and also enriches an understanding of how the UGT1 locus may be regulated at times where changes are apparent in the physiological levels of circulating hormones Homo sapiens
expression of theUGT1 locus in transgenic mice provides only a unique opportunity to examine the regulatory properties that control the tissue-specific and xenobiotic receptor-elicited expression patterns of the individual UGT1A genes and also enriches an understanding of how the UGT1 locus may be regulated at times where changes are apparent in the physiological levels of circulating hormones Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens P19224
-
-
Homo sapiens P22309
-
-
Homo sapiens P22310
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver of trangenic mice expressing the UGT1 locus of human. In maternal 14-day post-conception Tg-UGT1 mice, liver UGT1A1, UGT1A4, and UGT1A6 are induced, with the levels returning to near normal by birth. However, maternal liver UGT1A4 and UGT1A6 are dramatically elevated and maintained after birth, indicating that these proteins may play a critical role in maternal metabolism during lactation Homo sapiens
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liver of transgenic mice expressing the UGT1 locus of human. In maternal 14-day post-conception Tg-UGT1 mice, liver UGT1A1, UGT1A4, and UGT1A6 are induced, with the levels returning to near normal by birth. However, maternal liver UGT1A4 and UGT1A6 are dramatically elevated and maintained after birth, indicating that these proteins may play a critical role in maternal metabolism during lactation Homo sapiens
-

Synonyms

Synonyms Comment Organism
UGT1A1
-
Homo sapiens
UGT1A4
-
Homo sapiens
UGT1A6
-
Homo sapiens