Cloned (Comment) | Organism |
---|---|
coexpression of isozyme UGT2B7 with either CYP3A4, CYP1A2 or CYP2C9 cytochrome P450 enzymes in COS-1 cells, coexpression alters the kinetic properties of isozyme UGT2B7 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.2 | - |
morphine | isozyme UGT2B7 in COS-1 cell microsomes, pH 7.8, 37°C, in presence with CYP2C9 | Homo sapiens | |
0.38 | - |
morphine | isozyme UGT2B7 in COS-1 cell microsomes, pH 7.8, 37°C | Homo sapiens | |
0.48 | - |
morphine | isozyme UGT2B7 in COS-1 cell microsomes, pH 7.8, 37°C, in presence with CYP1A2 | Homo sapiens | |
1.18 | - |
morphine | liver microsomes, pH 7.8, 37°C | Homo sapiens | |
3.71 | - |
morphine | isozyme UGT2B7 in COS-1 cell microsomes, pH 7.8, 37°C, in presence with CYP3A4 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucuronate + morphine | Homo sapiens | regioselectivity of activity is altered by cytochrome P450 enzyme CYP3A4 so that the ratio of morphine activation/detoxification is increased | UDP + morphine-3-beta-D-glucuronide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P16662 | isozyme UGT2B7; isozyme UGT2B7 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
999 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | UGT2B7 interacts with CYP3A4, the latter reduces UGT2B7 activity in detergent n-octylglucoside treated recombinant COS-cell microsomes | Homo sapiens | ? | - |
? | |
UDP-glucuronate + morphine | regioselectivity of activity is altered by cytochrome P450 enzyme CYP3A4 so that the ratio of morphine activation/detoxification is increased | Homo sapiens | UDP + morphine-3-beta-D-glucuronide | - |
? | |
UDP-glucuronate + morphine | regioselective | Homo sapiens | UDP + morphine-3-beta-D-glucuronide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UGT | - |
Homo sapiens |
UGT2B7 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
assay at | Homo sapiens |