Cloned (Comment) | Organism |
---|---|
expression of isozymes in COS-1 cells | Homo sapiens |
expression of isozymes in COS-1 cells, DNA sequence determination and analysis of isozyme UGT1A9 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
curcumin | - |
Homo sapiens | |
nordihydroguaiaretic acid | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Homo sapiens | |
additional information | - |
additional information | kinetics, different isozymes, pH-values, and substrates | Homo sapiens | |
0.004 | - |
chrysin | isozyme UGT1A1, pH 7.6, 37°C | Homo sapiens | |
0.005 | - |
chrysin | isozyme UGT1A1, pH 6.4, 37°C | Homo sapiens | |
0.0068 | - |
phloretin | isozyme UGT1A8, pH 7.0, 37°C | Homo sapiens | |
0.0084 | - |
eugenol | isozyme UGT1A10, pH 7.6, 37°C | Homo sapiens | |
0.01 | - |
anthraflavic acid | isozyme UGT1A1, pH 6.4 or pH 7.6, 37°C | Homo sapiens | |
0.01 | - |
anthraflavic acid | isozyme UGT1A9, pH 7.6, 37°C | Homo sapiens | |
0.0159 | - |
eugenol | isozyme UGT1A7, pH 6.4, 37°C | Homo sapiens | |
0.0245 | - |
eugenol | isozyme UGT1A10, pH 6.4, 37°C | Homo sapiens | |
0.0257 | - |
eugenol | isozyme UGT1A7, pH 8.5, 37°C | Homo sapiens | |
0.045 | - |
phloretin | isozyme UGT1A10, pH 6.4, 37°C | Homo sapiens | |
0.0964 | - |
phloretin | isozyme UGT1A7, pH 6.4, 37°C | Homo sapiens | |
0.1 | - |
curcumin | isozyme UGT1A1, pH 6.4, 37°C | Homo sapiens | |
0.1 | - |
curcumin | isozyme UGT1A7, pH 7.6, 37°C | Homo sapiens | |
0.1 | - |
curcumin | isozyme UGT1A8, pH 7.0, 37°C | Homo sapiens | |
0.1 | - |
curcumin | isozymes UGT1A1 and UGT1A10, pH 6.4, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | isozymes are involved in detoxification of metabolites, drugs, toxins, and environmental chemicals via conjugation to glucuronic acid, physiological roles and overlapping activities | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60656 | isozyme UGT1A9 | - |
Homo sapiens | P22309 | isozyme UGT1A1 | - |
Homo sapiens | Q9HAW7 | isozyme UGT1A7 | - |
Homo sapiens | Q9HAW9 | isozyme UGT1A8 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | isozyme UGT1A7 | Homo sapiens | - |
bone marrow | isozyme UGT1A8 | Homo sapiens | - |
colon | isozyme UGT1A9 | Homo sapiens | - |
epithelium | mucosal epithelial layer of the gastrointestinal tract | Homo sapiens | - |
gastrointestinal tract | - |
Homo sapiens | - |
ileum | isozyme UGT1A1 | Homo sapiens | - |
jejunum | isozyme UGT1A1 | Homo sapiens | - |
jejunum | isozymes UGT1A9 | Homo sapiens | - |
jejunum | isozymes UGT1A9 and UGT1A1 | Homo sapiens | - |
kidney | isozyme UGT1A9 | Homo sapiens | - |
liver | isozyme UGT1A1 | Homo sapiens | - |
additional information | tissue distribution and expression patterns of isozymes UGT1A1, and UGT1A7-10 | Homo sapiens | - |
additional information | tissue distribution and expression patterns of isozymes, overview | Homo sapiens | - |
mucosa | mucosal epithelial layer of the gastrointestinal tract | Homo sapiens | - |
rectum | isozyme UGT1A9 | Homo sapiens | - |
stomach | isozyme UGT1A7 | Homo sapiens | - |
stomach | isozyme UGT1A8 | Homo sapiens | - |
stomach | isozymes UGT1A7 and UGT1A8 | Homo sapiens | - |
thyroid gland | isozyme UGT1A7 | Homo sapiens | - |
uterus | isozyme UGT1A1 | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
substrate specificities of isozymes | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | isozymes are involved in detoxification of metabolites, drugs, toxins, and environmental chemicals via conjugation to glucuronic acid, physiological roles and overlapping activities | Homo sapiens | ? | - |
? | |
additional information | substrate specificities of isozymes, overview | Homo sapiens | ? | - |
? | |
UDP-glucuronate + 2',4,4',6'-tetrahydroxychalcone | isozyme UGT1A1 | Homo sapiens | ? | - |
? | |
UDP-glucuronate + 2',4,4',6'-tetrahydroxychalcone | isozyme UGT1A7 | Homo sapiens | ? | - |
? | |
UDP-glucuronate + 2',4,4',6'-tetrahydroxychalcone | isozymes UGT1A1, UGT1A7, and UGT1A10 | Homo sapiens | ? | - |
? | |
UDP-glucuronate + Aloe-emodin | isozyme UGT1A7 | Homo sapiens | UDP + Aloe-emodin beta-D-glucuronide | - |
? | |
UDP-glucuronate + anthraflavic acid | isozyme UGT1A1 | Homo sapiens | UDP + anthraflavic acid 2-O-beta-D-glucuronide | - |
? | |
UDP-glucuronate + anthraflavic acid | isozyme UGT1A9 | Homo sapiens | UDP + anthraflavic acid 2-O-beta-D-glucuronide | - |
? | |
UDP-glucuronate + anthraflavic acid | isozymes UGT1A1, and UGT1A9 | Homo sapiens | UDP + anthraflavic acid 2-O-beta-D-glucuronide | - |
? | |
UDP-glucuronate + apigenin | isozyme UGT1A1 | Homo sapiens | UDP + apigenin beta-D-glucuronide | - |
? | |
UDP-glucuronate + apigenin | isozyme UGT1A7 | Homo sapiens | UDP + apigenin beta-D-glucuronide | - |
? | |
UDP-glucuronate + apigenin | isozymes UGT1A1, UGT1A7, and UGT1A10 | Homo sapiens | UDP + apigenin beta-D-glucuronide | - |
? | |
UDP-glucuronate + biochanin A | isozyme UGT1A1 | Homo sapiens | UDP + biochanin A beta-D-glucuronide | - |
? | |
UDP-glucuronate + biochanin A | isozyme UGT1A7 | Homo sapiens | UDP + biochanin A beta-D-glucuronide | - |
? | |
UDP-glucuronate + biochanin A | isozymes UGT1A1, UGT1A7, and UGT1A10 | Homo sapiens | UDP + biochanin A beta-D-glucuronide | - |
? | |
UDP-glucuronate + capsaicin | isozyme UGT1A1 | Homo sapiens | UDP + capsaicin beta-D-glucuronide | - |
? | |
UDP-glucuronate + capsaicin | isozyme UGT1A7 | Homo sapiens | UDP + capsaicin beta-D-glucuronide | - |
? | |
UDP-glucuronate + capsaicin | isozymes UGT1A1, UGT1A7, and UGT1A10 | Homo sapiens | UDP + capsaicin beta-D-glucuronide | - |
? | |
UDP-glucuronate + chrysin | isozyme UGT1A1 | Homo sapiens | UDP + chrysin beta-D-glucuronide | - |
? | |
UDP-glucuronate + chrysin | isozyme UGT1A7 | Homo sapiens | UDP + chrysin beta-D-glucuronide | - |
? | |
UDP-glucuronate + chrysin | isozyme UGT1A8 | Homo sapiens | UDP + chrysin beta-D-glucuronide | - |
? | |
UDP-glucuronate + chrysin | isozyme UGT1A9 | Homo sapiens | UDP + chrysin beta-D-glucuronide | - |
? | |
UDP-glucuronate + chrysin | isozymes UGT1A1, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 | Homo sapiens | UDP + chrysin beta-D-glucuronide | - |
? | |
UDP-glucuronate + curcumin | isozyme UGT1A1 | Homo sapiens | UDP + curcumin beta-D-glucuronide | - |
? | |
UDP-glucuronate + curcumin | isozyme UGT1A7 | Homo sapiens | UDP + curcumin beta-D-glucuronide | - |
? | |
UDP-glucuronate + curcumin | isozyme UGT1A8 | Homo sapiens | UDP + curcumin beta-D-glucuronide | - |
? | |
UDP-glucuronate + curcumin | isozymes UGT1A1, UGT1A7, UGT1A8, and UGT1A10 | Homo sapiens | UDP + curcumin beta-D-glucuronide | - |
? | |
UDP-glucuronate + eugenol | isozyme UGT1A7 | Homo sapiens | UDP + eugenol beta-D-glucuronide | - |
? | |
UDP-glucuronate + eugenol | isozymes UGT1A7, and UGT1A10 | Homo sapiens | UDP + eugenol beta-D-glucuronide | - |
? | |
UDP-glucuronate + genistein | isozyme UGT1A1 | Homo sapiens | UDP + genistein beta-D-glucuronide | - |
? | |
UDP-glucuronate + genistein | isozyme UGT1A7 | Homo sapiens | UDP + genistein beta-D-glucuronide | - |
? | |
UDP-glucuronate + genistein | isozymes UGT1A1, UGT1A7, and UGT1A10 | Homo sapiens | UDP + genistein beta-D-glucuronide | - |
? | |
UDP-glucuronate + naringenin | isozyme UGT1A1 | Homo sapiens | UDP + naringenin beta-D-glucuronide | - |
? | |
UDP-glucuronate + naringenin | isozyme UGT1A7 | Homo sapiens | UDP + naringenin beta-D-glucuronide | - |
? | |
UDP-glucuronate + naringenin | isozymes UGT1A1, UGT1A7, and UGT1A10 | Homo sapiens | UDP + naringenin beta-D-glucuronide | - |
? | |
UDP-glucuronate + phloretin | isozyme UGT1A7 | Homo sapiens | UDP + phloretin beta-D-glucuronide | - |
? | |
UDP-glucuronate + phloretin | isozyme UGT1A8 | Homo sapiens | UDP + phloretin beta-D-glucuronide | - |
? | |
UDP-glucuronate + phloretin | isozymes UGT1A7, UGT1A8, and UGT1A10 | Homo sapiens | UDP + phloretin beta-D-glucuronide | - |
? | |
UDP-glucuronate + quercetin | isozyme UGT1A1 | Homo sapiens | UDP + quercetin beta-D-glucuronide | - |
? | |
UDP-glucuronate + quercetin | isozyme UGT1A7 | Homo sapiens | UDP + quercetin beta-D-glucuronide | - |
? | |
UDP-glucuronate + quercetin | isozymes UGT1A1, UGT1A7, and UGT1A10 | Homo sapiens | UDP + quercetin beta-D-glucuronide | - |
? | |
UDP-glucuronate + quinazarin | isozyme UGT1A1 | Homo sapiens | UDP + quinazarin beta-D-glucuronide | - |
? | |
UDP-glucuronate + quinazarin | isozyme UGT1A7 | Homo sapiens | UDP + quinazarin beta-D-glucuronide | - |
? | |
UDP-glucuronate + quinazarin | isozymes UGT1A1, UGT1A7, and UGT1A10 | Homo sapiens | UDP + quinazarin beta-D-glucuronide | - |
? | |
UDP-glucuronate + quinizarin | isozyme UGT1A7 | Homo sapiens | UDP + quinizarin beta-D-glucuronide | - |
? | |
UDP-glucuronate + thymol | isozyme UGT1A7 | Homo sapiens | UDP + thymol beta-D-glucuronide | - |
? | |
UDP-glucuronate + thymol | isozymes UGT1A7, and UGT1A10 | Homo sapiens | UDP + thymol beta-D-glucuronide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UGT | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.4 | 7.6 | assay at | Homo sapiens |