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Literature summary for 2.4.1.17 extracted from
- Rapid simultaneous determination of metabolic clearance of multiple compounds catalyzed in vitro by recombinant human UDP-glucuronosyltransferases (2005), Anal. Biochem., 341, 105-112.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Homo sapiens | |
| 0.00048 | - |
8-hydroxyquinoline | isozyme UGT1A9, pH 7.4, 37°C | Homo sapiens |  |
| 0.0065 | - |
8-hydroxyquinoline | isozyme UGT1A6, pH 7.4, 37°C | Homo sapiens | |
| 0.016 | - |
8-hydroxyquinoline | isozyme UGT2B15, pH 7.4, 37°C | Homo sapiens | |
| 0.021 | - |
entacapone | isozyme UGT1A9, pH 7.4, 37°C | Homo sapiens | |
| 0.111 | - |
umbelliferone | isozyme UGT1A9, pH 7.4, 37°C | Homo sapiens | |
| 0.115 | - |
4-Methylumbelliferone | isozyme UGT1A1, pH 7.4, 37°C | Homo sapiens | |
| 0.149 | - |
4-Methylumbelliferone | isozyme UGT2B15, pH 7.4, 37°C | Homo sapiens | |
| 0.157 | - |
4-Methylumbelliferone | isozyme UGT1A6, pH 7.4, 37°C | Homo sapiens | |
| 0.18 | - |
4-Methylumbelliferone | isozyme UGT1A9, pH 7.4, 37°C | Homo sapiens | |
| 0.294 | - |
umbelliferone | isozyme UGT1A1, pH 7.4, 37°C | Homo sapiens | |
| 0.294 | - |
entacapone | isozyme UGT1A3, pH 7.4, 37°C | Homo sapiens | |
| 0.301 | - |
8-hydroxyquinoline | isozyme UGT2B7, pH 7.4, 37°C | Homo sapiens | |
| 0.335 | - |
4-Methylumbelliferone | isozyme UGT1A3, pH 7.4, 37°C | Homo sapiens | |
| 0.339 | - |
umbelliferone | isozyme UGT2B15, pH 7.4, 37°C | Homo sapiens | |
| 0.494 | - |
8-hydroxyquinoline | isozyme UGT1A3, pH 7.4, 37°C | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isozyme UGT1A6 | - |
| Homo sapiens | O60656 | isozyme UGT1A9; isozyme UGT1A9 | - |
| Homo sapiens | P16662 | isozyme UGT2B7; isozyme UGT2B7 | - |
| Homo sapiens | P22309 | isozyme UGT1A1; isozyme UGT1A1 | - |
| Homo sapiens | P35503 | isozyme UGT1A3; isozyme UGT1A3 | - |
| Homo sapiens | P54855 | isozyme UGT2B15; isozyme UGT2B15 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | substrate specificity of isozymes, overview | Homo sapiens | ? | - |
? | |
| UDP-glucuronate + 17beta-estriol | - |
Homo sapiens | UDP + estriol 17-beta-D-glucuronide | - |
? | |
| UDP-glucuronate + 4-methylumbelliferone | - |
Homo sapiens | UDP + 4-methylumbelliferone beta-D-glucuronide | - |
? | |
| UDP-glucuronate + 8-hydroxyquinoline | - |
Homo sapiens | UDP + 8-hydroxyquinoline beta-D-glucuronide | - |
? | |
| UDP-glucuronate + entacapone | - |
Homo sapiens | UDP + entacapone beta-D-glucuronide | - |
? | |
| UDP-glucuronate + paracetamol | - |
Homo sapiens | UDP + paracetamol beta-D-glucuronide | - |
? | |
| UDP-glucuronate + tolcapone | - |
Homo sapiens | UDP + tolcapone beta-D-glucuronide | - |
? | |
| UDP-glucuronate + umbelliferone | - |
Homo sapiens | UDP + umbelliferone beta-D-glucuronide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UDP-glucuronosyltransferase | - |
Homo sapiens |
| UGT | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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