Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diclofenac | inhibits the in vitro glucuronidation of morphine and codeine by liver microsomes | Homo sapiens | |
Dihydrocodeine | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.007 | - |
diclofenac | UGT2B1 | Rattus norvegicus | |
0.013 | - |
diclofenac | liver microsomes | Rattus norvegicus | |
0.013 | - |
diclofenac | UGT2B7 | Homo sapiens | |
0.016 | - |
diclofenac | - |
Rattus norvegicus | |
0.016 | - |
diclofenac | UGT1A9 | Homo sapiens | |
0.02 | - |
diclofenac | liver microsomes | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
overview | - |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
diclofenac + UDPalpha-D-glucuronate | UGT2B7 active at high rate, recombinant UGT1A9 active at moderate rate, UGT1A6 and UGT2B15 active at low rates | Homo sapiens | UDP + ? | - |
? | |
diclofenac + UDPalpha-D-glucuronate | recombinant UGT2B1 displays moderate rate | Rattus norvegicus | UDP + ? | - |
? | |
morphine + UDP-glucuronate | substrate for UGT2B7 | Homo sapiens | UDP + morphine 3,6-diglucuronide | - |
? | |
morphine + UDP-glucuronate | substrate for UGT2B1 | Rattus norvegicus | UDP + morphine 3,6-diglucuronide | - |
? | |
opiates + UDPglucuronate | substrate for UGT2B7 | Homo sapiens | opiates 6-O-glucuronides + UDP | - |
? |