Cloned (Comment) | Organism |
---|---|
different isozymes expressed in COS-7 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Diethyldithiocarbamic acid sodium salt | irreversible inhibitor | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Rattus norvegicus | |
additional information | - |
additional information | Km values for 31 xenobiotics reported | Homo sapiens | |
0.0066 | - |
androsterone | apparent Km for UGT2B7 | Homo sapiens | |
0.01 | - |
4-hydroxyestradiol | apparent Km for UGT2B7 | Homo sapiens | |
0.01 | - |
androsterone | apparent Km for UGT2B7(H) | Homo sapiens | |
0.011 | - |
hyodeoxycholic acid | apparent Km for UGT2B7(H) | Homo sapiens | |
0.014 | - |
4-hydroxyestrone | apparent Km for UGT2B7 | Homo sapiens | |
0.016 | - |
5alpha-androstane-3alpha,17beta diol | apparent Km for UGT1A4 | Homo sapiens | |
0.021 | - |
2-hydroxyestrone | apparent Km for UGT1A3 | Homo sapiens | |
0.024 | - |
bilirubin | apparent Km for UGT1A1 | Homo sapiens | |
0.024 | - |
2-hydroxyestrone | apparent Km for UGT1A1 | Homo sapiens | |
0.024 | - |
2-hydroxyestradiol | apparent Km for UGT1A3 | Homo sapiens | |
0.025 | - |
2-hydroxyestradiol | apparent Km for UGT1A1 | Homo sapiens | |
0.27 | - |
hyodeoxycholic acid | apparent Km for UGT2B4 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
endoplasmic reticulum membrane | - |
Rattus norvegicus | 5789 | - |
endoplasmic reticulum membrane | transmembrane protein with a lumenal domain consisting of about 95% of the polypeptide chain and a cytoplasmic domain of only 20 or so residues | Homo sapiens | 5789 | - |
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Homo sapiens | - |
- |
nuclear membrane | - |
Homo sapiens | 31965 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | - |
? | - |
? | |
additional information | Homo sapiens | wide variety of endogenous steroidal hormones, bile acids, retinoids and tyroid hormones glucuronidated by isozymes of UGT1A family | ? | - |
? | |
additional information | Homo sapiens | steroid hormones, bile acids, all trans retinoic acids and fatty acids glucuronidated by isozymes of UGTB2 family | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P19224 | overview | - |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose | - |
Homo sapiens | - |
adrenal gland | - |
Rattus norvegicus | - |
breast | - |
Homo sapiens | - |
gall bladder | - |
Homo sapiens | - |
gastrointestinal tract | - |
Homo sapiens | - |
intestine | - |
Homo sapiens | - |
kidney | - |
Rattus norvegicus | - |
kidney | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Homo sapiens | - |
lung | - |
Rattus norvegicus | - |
lung | - |
Homo sapiens | - |
mammary gland | - |
Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
skin | - |
Rattus norvegicus | - |
skin | - |
Homo sapiens | - |
stomach | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-hydroxyestradiol + UDPglucuronate | - |
Homo sapiens | UDP + 2-hydroxyestradiol O-glucuronide | - |
? | |
2-hydroxyestrone + UDPglucuronate | - |
Homo sapiens | 2-hydroxyestrone 2-O-glucuronide + UDP | - |
? | |
4-hydroxyestradiol + UDPglucuronate | - |
Homo sapiens | UDP + 4-hydroxyestradiol O-glucuronide | - |
? | |
4-hydroxyestrone + UDP-glucuronate | - |
Homo sapiens | UDP + 4-hydroxyestrone 4-O-glucuronide | - |
? | |
5alpha-androstane-3alpha,17beta-diol + UDP-glucuronate | - |
Homo sapiens | UDP + 5alpha-androstane-3alpha,17beta-diol O-glucuronide | - |
? | |
androsterone + UDPglucuronate | - |
Rattus norvegicus | UDP + androsterone O-glucuronide | - |
? | |
androsterone + UDPglucuronate | - |
Homo sapiens | UDP + androsterone O-glucuronide | - |
? | |
bilirubin + UDPglucuronate | - |
Rattus norvegicus | bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP | - |
? | |
bilirubin + UDPglucuronate | - |
Homo sapiens | bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP | - |
? | |
additional information | - |
Rattus norvegicus | ? | - |
? | |
additional information | wide variety of endogenous steroidal hormones, bile acids, retinoids and tyroid hormones glucuronidated by isozymes of UGT1A family | Homo sapiens | ? | - |
? | |
additional information | steroid hormones, bile acids, all trans retinoic acids and fatty acids glucuronidated by isozymes of UGTB2 family | Homo sapiens | ? | - |
? | |
morphine + UDP-glucuronate | - |
Rattus norvegicus | UDP + morphine 3,6-diglucuronide | - |
? | |
morphine + UDP-glucuronate | - |
Homo sapiens | UDP + morphine 3,6-diglucuronide | - |
? | |
scopoletin + UDPglucuronate | - |
Homo sapiens | UDP + scopoletin O-glucuronide | - |
? | |
testosterone + UDPglucuronate | - |
Rattus norvegicus | UDP + testosterone O-glucuronide | - |
? | |
UDP-D-glucuronate + androstane-3alpha,17beta-diol | - |
Homo sapiens | UDP + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | apparent homodimers and heterodimers of UGT2B1 and UGT1A6 | Homo sapiens |
? | all values determined by SDS-PAGE | Rattus norvegicus |
? | all values determined by SDS-PAGE | Homo sapiens |