Activating Compound | Comment | Organism | Structure |
---|---|---|---|
3-methylcholanthrene | induces glucuronidation of planar phenols | Rattus norvegicus | |
Phenobarbital | - |
Homo sapiens | |
Phenobarbital | induces bilirubin glucuronidation | Rattus norvegicus | |
UDP-N-acetylglucosamine | presumed physiological activator | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expressed in COS-7 cells | Rattus norvegicus |
several UGT cloned. Persistently increased expression of phenol-UGT in rat hepatocyte nodules, hepatoma H4IIE cells and various rat liver epithelial cell lines. Expressed in human lung carcinoma A549 cells and human breast cancer MCF7 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,2,2-triphenyl-UDP | selective inhibitor | Rattus norvegicus | |
7,7,7-Triphenylheptanoic acid | competitive to bilirubin | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | - |
Rattus norvegicus | 5789 | - |
endoplasmic reticulum membrane | sequencing data indicate that the enzymes are anchored in the membrane by a carboxy-terminal hydrophobic domain, with a bulk of the polypeptide chain located within the cisternal lumen of the endoplasmic reticulum | Homo sapiens | 5789 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
overview | - |
Rattus norvegicus | - |
overview | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | Gunn rat strain, inducible phenol-UGT synthesized in the truncated form is not the result of a posttranslational modification | Rattus norvegicus |
Purification (Comment) | Organism |
---|---|
two isozymes | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bilirubin + UDPglucuronate | - |
Homo sapiens | bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP | - |
? | |
bilirubin + UDPglucuronate | expressed after birth | Rattus norvegicus | bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP | - |
? | |
additional information | substrate specificity determinates by amino acid sequences in the variable amino-terminal half of the enzyme molecule | Rattus norvegicus | ? | - |
? | |
planar phenols + UDPglucuronate | expressed before birth | Rattus norvegicus | UDP + phenylglucuronides | - |
? |