Activating Compound | Comment | Organism | Structure |
---|---|---|---|
bilirubin | stimulates the glucoronidation of 4-nitrophenol and morphine | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
different isozymes expressed in COS-7 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-nitrophenol glucuronide | inhibits 4-nitrophenol glucuronidation | Rattus norvegicus | |
codeine | competitive inhibitor to morphine-UDPGT | Rattus norvegicus | |
cyproheptadine | - |
Rattus norvegicus | |
desmethylcyproheptadine | - |
Rattus norvegicus | |
flunitrazepam | competitive inhibitor to morphine glucuronidation | Rattus norvegicus | |
morphine 3-glucuronide | inhibits morphine glucuronidation | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Rattus norvegicus | - |
- |
microsome | - |
Oryctolagus cuniculus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
x * 50000, 17beta-hydroxysteroid-UDPGT | Rattus norvegicus |
52000 | - |
x * 52000, 3alpha-hydroxysteroid-UDPGT | Rattus norvegicus |
53000 | - |
x * 53000 estriol-UDPGT | Homo sapiens |
56000 | - |
x * 56000, morphine-UDPGT | Rattus norvegicus |
56000 | - |
x * 56000, 4-nitrophenol-UDPGT | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | elimination of lipid-soluble endogenous compounds and xenobiotics | ? | - |
? | |
additional information | Rattus norvegicus | elimination of lipid-soluble endogenous compounds and xenobiotics | ? | - |
? | |
additional information | Oryctolagus cuniculus | elimination of lipid-soluble endogenous compounds and xenobiotics | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
overview | - |
Oryctolagus cuniculus | - |
rabbit | - |
Rattus norvegicus | - |
overview | - |
Purification (Comment) | Organism |
---|---|
method | Rattus norvegicus |
method | Oryctolagus cuniculus |
two isozymes purified with chromatofocusing and UDP-hexanolamine Sepharose 4B affinity chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
estriol + UDPglucuronate | - |
Homo sapiens | UDP + estriol-16 alpha-glucuronide | - |
? | |
additional information | elimination of lipid-soluble endogenous compounds and xenobiotics | Homo sapiens | ? | - |
? | |
additional information | elimination of lipid-soluble endogenous compounds and xenobiotics | Rattus norvegicus | ? | - |
? | |
additional information | elimination of lipid-soluble endogenous compounds and xenobiotics | Oryctolagus cuniculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 56000, morphine-UDPGT | Rattus norvegicus |
? | x * 56000, 4-nitrophenol-UDPGT | Rattus norvegicus |
? | x * 52000, 3alpha-hydroxysteroid-UDPGT | Rattus norvegicus |
? | x * 53000 estriol-UDPGT | Homo sapiens |
? | all values determined by SDS-PAGE | Homo sapiens |
? | all values determined by SDS-PAGE | Rattus norvegicus |
? | all values determined by SDS-PAGE | Oryctolagus cuniculus |
? | x * 50000, 17beta-hydroxysteroid-UDPGT | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.08 | - |
cyproheptadine | morphine-UDPGT | Rattus norvegicus | |
1.3 | - |
FNZ | - |
Rattus norvegicus | |
4 | - |
desmethylcyproheptadine | - |
Rattus norvegicus |